NCKIPSD and TSEN54

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NCKIPSD	TSEN54
Description		NCK interacting protein with SH3 domain	tRNA splicing endonuclease subunit 54
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	TRNA-intron Endonuclease Complex Nucleoplasm Nucleolus
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Myosin Binding SH3 Domain Binding Arp2/3 Complex Binding	Protein Binding
	Biological Process	Endocytosis Cytoskeleton Organization Positive Regulation Of Neuron Projection Development	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	tRNA processing in the nucleus
Drugs
Diseases
GWAS		Anorexia nervosa ( 31308545) Blood protein levels ( 28240269) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Myocardial infarction ( 33532862) Parkinson's disease ( 28892059) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	Deep white matter hyperintensities ( 32517579) FEV1 ( 30804560) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Platelet count ( 32888494) Plateletcrit ( 32888494) Sight-threatening diabetic retinopathy in type 2 diabetes ( 26188370)
Interacting Genes		42 interacting genes: ABI2 ARHGEF7 BAIAP2 CCDC187 CPNE2 CYSLTR2 DIAPH2 DIAPH3 DLG4 DMRTB1 ENKD1 FASLG GAS7 GRB2 HSPB1 ITGB1 KHDRBS1 LGALS4 MAPK3 MED25 NCK1 NCK2 PIN1 PKP2 POLR3C PRPF31 PSMD9 PSORS1C2 RBM22 RBP7 RXFP3 SHANK3 SNRPC SORBS3 STAC TSEN54 VEZF1 WAS WASL YWHAG ZBTB47 ZC2HC1C	21 interacting genes: BRCA1 CCDC57 CLP1 CSNK2B GOLGA6L9 IRF4 KPNA5 KRT31 LHX3 LHX4 LMO2 MCPH1 MRPL38 NAA10 NCKIPSD NFKBID RINT1 TRIM23 TRIML2 TSEN2 ZMYND12
Entrez ID		51517	283989
HPRD ID		09450	12291
Ensembl ID		ENSG00000213672	ENSG00000182173
Uniprot IDs		Q9NZQ3	Q7Z6J9
PDB IDs		6DEC 6DED 6DEE
Enriched GO Terms of Interacting Partners?
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