TXNDC5 and PRDX2

Number of citations of the paper that reports this interaction (PubMedID 23713588)
20

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		TXNDC5	PRDX2
Description		thioredoxin domain containing 5	peroxiredoxin 2
Image
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding	Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity
	Biological Process	Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance	Defense Response To Tumor Cell Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Cellular Response To Stress Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Homeostasis Of Number Of Cells Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			3-sulfino-L-alanine N-Carbamoyl-Alanine Copper
Diseases
GWAS		Blood protein levels ( 30072576 29875488) High chromosomal aberration frequency (chromatid type) ( 31586183) Mean corpuscular hemoglobin ( 32888494) Pelvic organ prolapse ( 32184442)	Platelet distribution width ( 32888494)
Interacting Genes		28 interacting genes: APP AR BLZF1 EDEM3 EFEMP1 FLACC1 GMPPB KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 LHX4 MGAT5B NOTCH2NLA OGT PJA1 PRDX2 RAB3IP SPRY2 TRIM23 TRIM42 TRIP6 UBQLN2	25 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PRDX4 PSEN1 RNF32 SAT1 SUMO4 TXNDC5 TYK2 UTY YWHAZ
Entrez ID		81567	7001
HPRD ID		18249	02763
Ensembl ID		ENSG00000239264	ENSG00000167815
Uniprot IDs		A0A024QZV0 Q8NBS9	P32119 V9HW12
PDB IDs		2DIZ 3UJ1 3UVT 3WGD 3WGE 3WGX	1QMV 5B8A 5B8B 5IJT
Enriched GO Terms of Interacting Partners?
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