PRDX2 and EXOC6

Number of citations of the paper that reports this interaction (PubMedID 21163940)
36

Data Source:
BioGRID (two hybrid)

		PRDX2	EXOC6
Description		peroxiredoxin 2	exocyst complex component 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Exocyst Cytosol Plasma Membrane Membrane Growth Cone Perinuclear Region Of Cytoplasm Flemming Body
	Molecular Function	Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity	Protein Binding
	Biological Process	Defense Response To Tumor Cell Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Cellular Response To Stress Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Homeostasis Of Number Of Cells Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Intracellular Protein Transport Exocytosis Golgi To Plasma Membrane Transport Vesicle Tethering Involved In Exocytosis
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs		3-sulfino-L-alanine N-Carbamoyl-Alanine Copper
Diseases
GWAS		Platelet distribution width ( 32888494)	Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Body mass index ( 28892062) Coronary artery disease ( 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) Glaucoma (primary open-angle) ( 29449654) Hemoglobin A1c levels ( 29403010) High density lipoprotein cholesterol levels ( 29403010 33339817) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Intraocular pressure ( 30054594) Metabolic syndrome ( 31589552) Platelet distribution width ( 32888494) Refractive error ( 32231278) Total bilirubin levels ( 29403010)
Interacting Genes		25 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PRDX4 PSEN1 RNF32 SAT1 SUMO4 TXNDC5 TYK2 UTY YWHAZ	12 interacting genes: APP CYP2C8 ECSIT EXOC5 EXOSC1 GCDH LOXL4 MAST1 NOS3 PRDX2 PSEN2 RNF32
Entrez ID		7001	54536
HPRD ID		02763	10216
Ensembl ID		ENSG00000167815	ENSG00000138190
Uniprot IDs		P32119 V9HW12	A5YP36 B2RDH5 B3KXY5 B7Z6G5 E7EW84 Q8TAG9
PDB IDs		1QMV 5B8A 5B8B 5IJT
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?