EFHC2 and RECK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		EFHC2	RECK
Description		EF-hand domain containing 2	reversion inducing cysteine rich protein with kazal motifs
Image			No pdb structure
GO Annotations	Cellular Component	Microtubule Axoneme Ciliary Basal Body Mitotic Spindle	Extracellular Region Plasma Membrane Membrane Anchored Component Of Membrane Wnt Signalosome
	Molecular Function	Calcium Ion Binding Protein Binding Alpha-tubulin Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Wnt-protein Binding Coreceptor Activity Involved In Canonical Wnt Signaling Pathway
	Biological Process	Mitotic Cytokinesis Mitotic Spindle Organization Regulation Of Neuron Projection Development Cilium-dependent Cell Motility Cellular Response To Leukemia Inhibitory Factor	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity
Pathways			Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Glaucoma (primary open-angle) ( 33627673) Mean arterial pressure ( 29403010)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)
Interacting Genes		100 interacting genes: - AASDHPPT ARHGEF5 ARMC7 CABP2 CACNB4 CARD9 CCDC102B CCDC120 CCDC13 CCDC57 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CPNE2 CPNE7 CYFIP1 DCLK1 DDX6 DGCR6 DRC7 EDC3 EFHC1 EGLN3 EMD ENKD1 ESRRG EXOC8 EXOSC5 FAM107A FAM124B FAM214B FAM221B FBXL19 GEM GLYCTK GOLGA1 GPKOW GRB2 GYS1 HDAC4 HGS HNRNPLL INPP5J JAKMIP2 KANK2 KCTD7 KIF9 L3MBTL2 LMNB2 LMO2 LNX1 LONRF1 MAGOHB MAPK9 MID2 MISP MYLIP MYO5B NCDN NCK2 NDOR1 NEK6 NFKBID NME7 NR3C1 PBLD PHF1 PIBF1 PICK1 PLOD3 POLR1C PRPF18 PTK6 QARS1 RAD51D RCOR3 RECK RHOBTB3 RUNX1T1 SNRNP25 SOGA1 SPATA18 SPG21 STK16 TBC1D1 TBC1D22B TEKT4 TRIM42 TRIM50 TSSK3 TUBGCP4 TXK U2AF1 USP2 ZBTB16 ZFHX3 ZZZ3	44 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL RPS6KA1 SIGMAR1 SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704
Entrez ID		80258	8434
HPRD ID		06540	05567
Ensembl ID		ENSG00000183690	ENSG00000122707
Uniprot IDs		Q5JST6	A8K9D8 O95980 Q6P9E2
PDB IDs		2Z13 2Z14
Enriched GO Terms of Interacting Partners?
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