CEP63 and TBC1D15

Number of citations of the paper that reports this interaction (PubMedID 26638075)
175

Data Source:
BioGRID (proximity labelling technology, two hybrid, two hybrid)

		CEP63	TBC1D15
Description		centrosomal protein 63	TBC1 domain family member 15
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Centrosome Centriole Cytosol	Extracellular Region Cytoplasm
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	DNA Damage Checkpoint Signaling Centriole Replication Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation	Intracellular Protein Transport Regulation Of GTPase Activity Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	TBC/RABGAPs
Drugs
Diseases
GWAS		Height ( 18391952) Hip circumference adjusted for BMI ( 34021172) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Inferior parietal cortex volume ( 31530798) Metabolite levels ( 23823483)
Interacting Genes		67 interacting genes: ALOX5 ARFIP2 ARNT2 BFSP2 BRPF1 CAMKK2 CAPN7 CCDC14 CCDC187 CCHCR1 CCNI CDK1 CEP57 CEP57L1 CWF19L2 DAXX DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 FEM1C GSE1 HAUS1 HGS INTS6L KANK2 KXD1 MACF1 MBIP MNS1 NCOR2 NDC80 NDEL1 NXT2 PCNX4 PIBF1 POLR3C PPP1R13B PPP4R1 RCOR3 ROGDI SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 STAG1 SYNE1 SYT17 TBC1D15 TBC1D22B TSG101 TSGA10IP TSHZ3 TXLNA TXLNB USHBP1 USP2 ZCCHC10 ZNF148 ZNF250 ZNF774	9 interacting genes: CALCOCO1 CEP63 FIS1 OPTN RAB5A RAB5B RAB5C TAX1BP1 UBC
Entrez ID		80254	64786
HPRD ID		07826	15470
Ensembl ID		ENSG00000182923	ENSG00000121749
Uniprot IDs		Q96MT8	A8K8E1 Q8TC07
PDB IDs		6CSU 6CSV
Enriched GO Terms of Interacting Partners?
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