TBC1D15 and FIS1

Number of citations of the paper that reports this interaction (PubMedID 23077178)
52

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology, pull down)

		TBC1D15	FIS1
Description		TBC1 domain family member 15	fission, mitochondrial 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm	Mitochondrion Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Cytosol Membrane Integral Component Of Mitochondrial Outer Membrane Protein-containing Complex
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Intracellular Protein Transport Regulation Of GTPase Activity Activation Of GTPase Activity Regulation Of Cilium Assembly	Mitochondrial Fission Autophagy Of Mitochondrion Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Positive Regulation Of Cytosolic Calcium Ion Concentration Mitochondrial Fusion Regulation Of Mitochondrion Organization Response To Muscle Activity Peroxisome Fission Response To Nutrient Levels Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Mitochondrion Morphogenesis Cellular Response To Glucose Stimulus Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Targeting To Membrane Cellular Response To Toxic Substance Cellular Response To Peptide Response To Fluoride Negative Regulation Of ATP Metabolic Process Cellular Response To Thapsigargin Response To Flavonoid Response To Hypobaric Hypoxia Negative Regulation Of Fatty Acid Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		TBC/RABGAPs	Class I peroxisomal membrane protein import
Drugs
Diseases
GWAS		Inferior parietal cortex volume ( 31530798) Metabolite levels ( 23823483)	Rheumatoid arthritis ( 30891314)
Interacting Genes		9 interacting genes: CALCOCO1 CEP63 FIS1 OPTN RAB5A RAB5B RAB5C TAX1BP1 UBC	31 interacting genes: A2M ABHD6 APH1A BCAP31 CREB3 DNM1L EBP ERGIC3 FAM209A FAM210B FFAR2 JAGN1 KASH5 KCNJ6 KMT2E MARCHF5 MMGT1 NOS3 PIGP RNASEK SCN3B SLC10A6 SLC14A1 SLC22A1 SLC22A2 SPCS1 TBC1D15 TMEM14B TMPPE UBC VKORC1
Entrez ID		64786	51024
HPRD ID		15470	12352
Ensembl ID		ENSG00000121749	ENSG00000214253
Uniprot IDs		A8K8E1 Q8TC07	Q9Y3D6
PDB IDs			1NZN 1PC2
Enriched GO Terms of Interacting Partners?
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