NAA50 and BHLHE40

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NAA50	BHLHE40
Description		N-alpha-acetyltransferase 50, NatE catalytic subunit	basic helix-loop-helix family member e40
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol NatA Complex Extracellular Exosome	Chromatin Nucleus Cytoplasm Nuclear Body
	Molecular Function	Peptide Alpha-N-acetyltransferase Activity Protein Binding N-acetyltransferase Activity H4 Histone Acetyltransferase Activity Peptidyl-lysine Acetyltransferase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	N-terminal Protein Amino Acid Acetylation Mitotic Sister Chromatid Cohesion Histone Acetylation Establishment Of Mitotic Sister Chromatid Cohesion Histone H4 Acetylation Mitotic Sister Chromatid Cohesion, Centromeric	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Anterior/posterior Pattern Specification Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis
Pathways			BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Cognitive function in longevity ( 33607172) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Psoriasis vulgaris ( 26626624) Serum alkaline phosphatase levels ( 33547301) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		6 interacting genes: BHLHE40 JMJD6 NAA10 NAA15 NPHP3 OTX2	91 interacting genes: AAMP AANAT APH1A ARNTL ATXN1 BHLHE41 BRD7 BYSL CALML3 CCNK CDPF1 CHD3 COX5B CREM DAB1 DAZAP2 DVL3 EHHADH ENO1 FAM83A FBLN1 FXR1 GMCL2 GPSM1 HDAC1 HIVEP1 HNRNPLL KLHDC7B KRTAP1-3 KRTAP19-1 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LARP4 LASP1 LMO3 MAGED1 MCRS1 MYOD1 NAA50 NEK6 NOC4L NUMBL OXNAD1 PDE6G PFDN5 PHF1 PLEKHB2 POU6F2 PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E RAD54L2 RBFOX1 RBM23 RBPMS RBPMS2 RHOBTB3 RHOJ ROR2 SETDB1 SIN3A SMAP2 SMARCB1 SMYD1 SOGA1 SOX15 STAT3 STK19 TCF3 TENT5A TENT5B TLE5 TOB2 TOLLIP TTC23 TXNL4B UBE2I USP54 VAC14 VENTX VIM WT1 ZFHX3 ZHX1
Entrez ID		80218	8553
HPRD ID		14350	16050
Ensembl ID		ENSG00000121579	ENSG00000134107
Uniprot IDs		E7EQ69 Q9GZZ1	O14503 Q6IB83
PDB IDs		2OB0 2PSW 3TFY 4X5K 6PPL 6PW9 6WF3 6WF5 6WFG 6WFK 6WFN 6WFO
Enriched GO Terms of Interacting Partners?
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