BHLHE40 and SMYD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		BHLHE40	SMYD1
Description		basic helix-loop-helix family member e40	SET and MYND domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Nuclear Body	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Transcription Corepressor Activity Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Anterior/posterior Pattern Specification Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis	Chromatin Remodeling Heart Development Positive Regulation Of Myotube Differentiation Histone Lysine Methylation Skeletal Muscle Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Cognitive function in longevity ( 33607172) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Psoriasis vulgaris ( 26626624) Serum alkaline phosphatase levels ( 33547301) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Night sleep phenotypes ( 27126917) Retinal detachment or retinal break ( 31816047)
Interacting Genes		91 interacting genes: AAMP AANAT APH1A ARNTL ATXN1 BHLHE41 BRD7 BYSL CALML3 CCNK CDPF1 CHD3 COX5B CREM DAB1 DAZAP2 DVL3 EHHADH ENO1 FAM83A FBLN1 FXR1 GMCL2 GPSM1 HDAC1 HIVEP1 HNRNPLL KLHDC7B KRTAP1-3 KRTAP19-1 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LARP4 LASP1 LMO3 MAGED1 MCRS1 MYOD1 NAA50 NEK6 NOC4L NUMBL OXNAD1 PDE6G PFDN5 PHF1 PLEKHB2 POU6F2 PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E RAD54L2 RBFOX1 RBM23 RBPMS RBPMS2 RHOBTB3 RHOJ ROR2 SETDB1 SIN3A SMAP2 SMARCB1 SMYD1 SOGA1 SOX15 STAT3 STK19 TCF3 TENT5A TENT5B TLE5 TOB2 TOLLIP TTC23 TXNL4B UBE2I USP54 VAC14 VENTX VIM WT1 ZFHX3 ZHX1	44 interacting genes: ARID5A BACH2 BHLHE40 C11orf1 C11orf16 C11orf53 CCDC113 CCDC33 DISC1 DVL1 FAM166A FAM204A FAM83A FAM86C1P H3-5 HDAC2 HDAC3 HDHD3 HMG20A HOMEZ KIF16B KRT35 LENG8 MDFI MEOX2 MYH7B NACA NEFL OGDHL PATZ1 POU6F2 PRR22 RBM4B RSPH6A RUSC1 SNX11 SPAG8 TBRG1 TTC33 USP54 UTP14A WDR77 ZBTB3 ZBTB44
Entrez ID		8553	150572
HPRD ID		16050	06025
Ensembl ID		ENSG00000134107	ENSG00000115593
Uniprot IDs		O14503 Q6IB83	E9PHG3 Q5HYE8 Q8NB12
PDB IDs
Enriched GO Terms of Interacting Partners?
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