FAM124B and TRIM8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FAM124B	TRIM8
Description		family with sequence similarity 124 member B	tripartite motif containing 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion	Cytosol PML Body
	Molecular Function	Protein Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process		Positive Regulation Of Autophagy Protein Ubiquitination Stem Cell Population Maintenance Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Viral Release From Host Cell
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Familial squamous cell lung carcinoma ( 29924316)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Feeling nervous ( 29500382) Hip circumference adjusted for BMI ( 34021172) Prostate cancer ( 23535732) Pulse pressure ( 30578418) Refractive error ( 32231278) Schizophrenia ( 25056061 30285260) Serum alkaline phosphatase levels ( 33547301) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 26192919) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		68 interacting genes: ABI1 ABI3 ADAMTSL4 BHLHB9 BIRC7 BLZF1 CARD9 CCDC153 CCDC85B CUL3 CYSRT1 EFEMP2 EFHC2 ESM1 GIGYF1 GKAP1 GOLGA2 GPRASP2 GRB7 HSF2BP IHO1 IKZF3 ISCA2 KCTD6 KCTD9 KIAA1958 KRT19 KRT31 KRT40 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP5-9 KRTAP9-3 LHX3 LZTS2 MBD3L1 MDFI MIPOL1 MKRN3 MTUS2 MYF5 NADK NOTCH2NLA RBPMS RINT1 RSPH3 SEPTIN14 SH2B2 SP7 SSX2IP TCF4 TLE5 TRAF2 TRIM37 TRIM42 TRIM54 TRIM8 TRIM9 TRIP6 USHBP1 USP54 WDR83 ZBED1 ZNF69 ZNF774 ZRANB1	64 interacting genes: ADD3 BRAP CATSPER1 CBL CCNH DCUN1D1 ESR1 FAM124B HOXA1 ITSN1 LNX1 LONRF1 MAGEC2 MKRN3 MSL2 MTURN NUDT10 OTUB2 PCGF5 RAD18 RAD23A RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF168 RNF181 RNF41 RNF7 SIAH1 SOCS1 TICAM1 TNFAIP3 TNPO2 TNS2 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UBXN7 UHRF2 USP2 USP21 USP39 USP5 USP7 XIAP YOD1
Entrez ID		79843	81603
HPRD ID		08663	06934
Ensembl ID		ENSG00000124019	ENSG00000171206
Uniprot IDs		Q9H5Z6	Q9BZR9
PDB IDs
Enriched GO Terms of Interacting Partners?
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