TRIM8 and SIAH1

Number of citations of the paper that reports this interaction (PubMedID 22493164)
7

Data Source:
BioGRID (two hybrid)

		TRIM8	SIAH1
Description		tripartite motif containing 8	siah E3 ubiquitin protein ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol PML Body	Nucleus Cytoplasm Early Endosome Cytosol Plasma Membrane Beta-catenin Destruction Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Autophagy Protein Ubiquitination Stem Cell Population Maintenance Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Viral Release From Host Cell	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Ubiquitination Protein Catabolic Process Protein Destabilization Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Amyloid Fibril Formation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Interferon gamma signaling	Netrin-1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Feeling nervous ( 29500382) Hip circumference adjusted for BMI ( 34021172) Prostate cancer ( 23535732) Pulse pressure ( 30578418) Refractive error ( 32231278) Schizophrenia ( 25056061 30285260) Serum alkaline phosphatase levels ( 33547301) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 26192919) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Height ( 28552196) Mean corpuscular hemoglobin ( 32888494) Waist circumference ( 28552196)
Interacting Genes		64 interacting genes: ADD3 BRAP CATSPER1 CBL CCNH DCUN1D1 ESR1 FAM124B HOXA1 ITSN1 LNX1 LONRF1 MAGEC2 MKRN3 MSL2 MTURN NUDT10 OTUB2 PCGF5 RAD18 RAD23A RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF168 RNF181 RNF41 RNF7 SIAH1 SOCS1 TICAM1 TNFAIP3 TNPO2 TNS2 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UBXN7 UHRF2 USP2 USP21 USP39 USP5 USP7 XIAP YOD1	152 interacting genes: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 AXIN1 BAG1 BAG3 BAG4 BCL6 CACYBP CAPG CCDC198 CDC23 CDC34 CDK5R1 DAB1 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 H4-16 HCFC1 HIF1AN HIPK2 HIPK3 INHA IQCN KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIF1B KIF22 KIFC3 KLF10 LACTB2 LANCL2 LMNA M1AP MAB21L1 MAP3K5 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 NANOS2 NANOS3 NECTIN2 NELFA NOL6 NTAQ1 NUMB NUMBL OPRM1 OTUB2 PARD6B PEG10 PEG3 PFKM PHC1 PHC2 PIAS2 PIAS3 PIMREG PKD1 POU2AF1 PRPF31 PRR20A PRR20B PRR20C PRR20D PRR20E PTPMT1 PUF60 PYGB QRICH1 RAB33A RAB33B RAD51AP1 RAD54L2 RAPH1 RBBP8 RICTOR RPL27A RPS19BP1 RXRB SDCBP SFMBT2 SH3RF1 SLC9A3R2 SNCAIP SPATA4 SPATC1L SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671 ZYX
Entrez ID		81603	6477
HPRD ID		06934	03736
Ensembl ID		ENSG00000171206	ENSG00000196470
Uniprot IDs		Q9BZR9	Q8IUQ4
PDB IDs			2A25 4C9Z 4CA1 4I7B 4I7C 4I7D 4X3G 5WZZ
Enriched GO Terms of Interacting Partners?
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