FA2H and PEX12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FA2H	PEX12
Description		fatty acid 2-hydroxylase	peroxisomal biogenesis factor 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Cytosol Peroxisomal Importomer Complex
	Molecular Function	Iron Ion Binding Protein Binding Heme Binding Fatty Acid Alpha-hydroxylase Activity	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding
	Biological Process	Sebaceous Gland Cell Differentiation Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Glucosylceramide Biosynthetic Process Galactosylceramide Biosynthetic Process Sphingolipid Biosynthetic Process Lipid Modification Central Nervous System Myelin Maintenance Peripheral Nervous System Myelin Maintenance Regulation Of Cell Population Proliferation Regulation Of Hair Cycle Plasma Membrane Raft Organization Ceramide Biosynthetic Process Establishment Of Skin Barrier	Protein Monoubiquitination Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix
Pathways		Sphingolipid de novo biosynthesis	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases
GWAS		General cognitive ability ( 25383866) Pancreatic cancer ( 25086665) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		31 interacting genes: AQP6 ARMC12 ASGR2 CD79A CREB3 CREB3L1 DLG2 EBP ELOVL4 ERGIC3 ERLIN1 FAM209A FCER1G GPR152 GPR37 GPX8 LMNA MARCHF8 MSR1 PEX12 PGRMC2 RIC3 SGPL1 SLC10A1 SLC10A6 SYT2 TLCD4 TMEM14B TMEM41A TMX2 UBQLN4	36 interacting genes: ACSL5 ADIPOQ BNIP2 BTN2A2 C5orf46 CLDN10 COL8A2 CXCL16 CYBC1 DNAJC30 ERMP1 FA2H FKBP8 FXYD6 GJB2 IER3IP1 MARCHF2 MGLL NKG7 NRM PEX10 PEX19 PEX5 PNLIPRP1 PTPN9 RBFA SEC22A SEC61G SMCO4 SRGN STX8 THSD7B TMEM11 TMEM222 TREX1 TTPA
Entrez ID		79152	5193
HPRD ID		16873	03455
Ensembl ID		ENSG00000103089	ENSG00000108733
Uniprot IDs		Q7L5A8	O00623
PDB IDs
Enriched GO Terms of Interacting Partners?
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