FA2H and MSR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FA2H	MSR1
Description		fatty acid 2-hydroxylase	macrophage scavenger receptor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Collagen Trimer Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Endocytic Vesicle Membrane Low-density Lipoprotein Particle
	Molecular Function	Iron Ion Binding Protein Binding Heme Binding Fatty Acid Alpha-hydroxylase Activity	Amyloid-beta Binding Scavenger Receptor Activity Protein Binding Low-density Lipoprotein Particle Binding Cargo Receptor Activity
	Biological Process	Sebaceous Gland Cell Differentiation Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Glucosylceramide Biosynthetic Process Galactosylceramide Biosynthetic Process Sphingolipid Biosynthetic Process Lipid Modification Central Nervous System Myelin Maintenance Peripheral Nervous System Myelin Maintenance Regulation Of Cell Population Proliferation Regulation Of Hair Cycle Plasma Membrane Raft Organization Ceramide Biosynthetic Process Establishment Of Skin Barrier	Receptor-mediated Endocytosis Phagocytosis, Engulfment Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Cholesterol Transport Plasma Lipoprotein Particle Clearance Lipoprotein Transport Cellular Response To Organic Cyclic Compound Amyloid-beta Clearance
Pathways		Sphingolipid de novo biosynthesis	Scavenging by Class A Receptors Scavenging by Class A Receptors
Drugs
Diseases
GWAS		General cognitive ability ( 25383866) Pancreatic cancer ( 25086665) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	Alcohol dependence ( 26365420) Blood protein levels ( 23696881) HDL cholesterol levels in HIV infection ( 33109212) Hip circumference adjusted for BMI ( 28552196) Neurological blood protein biomarker levels ( 31320639) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		31 interacting genes: AQP6 ARMC12 ASGR2 CD79A CREB3 CREB3L1 DLG2 EBP ELOVL4 ERGIC3 ERLIN1 FAM209A FCER1G GPR152 GPR37 GPX8 LMNA MARCHF8 MSR1 PEX12 PGRMC2 RIC3 SGPL1 SLC10A1 SLC10A6 SYT2 TLCD4 TMEM14B TMEM41A TMX2 UBQLN4	8 interacting genes: ADRB2 ATP6V0C FA2H HSPA1A LEPROTL1 MALL NKG7 SEC22A
Entrez ID		79152	4481
HPRD ID		16873	01092
Ensembl ID		ENSG00000103089	ENSG00000038945
Uniprot IDs		Q7L5A8	P21757
PDB IDs
Enriched GO Terms of Interacting Partners?
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