CA4 and XPO1

		CA4	XPO1
Description		carbonic anhydrase 4	exportin 1
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GO Annotations	Cellular Component	Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Ribonucleoprotein Complex
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Hydro-lyase Activity	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding Protein Domain Specific Binding Small GTPase Binding
	Biological Process	One-carbon Metabolic Process Bicarbonate Transport	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II Protein Export From Nucleus Nucleocytoplasmic Transport Response To Xenobiotic Stimulus Regulation Of Centrosome Duplication Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Ribosome Biogenesis Regulation Of Protein Export From Nucleus MRNA Transport
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation Heme signaling
Drugs		Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Zonisamide Trichlormethiazide Diclofenamide Brinzolamide Ellagic acid Sodium carbonate	Selinexor
Diseases
GWAS			Atrial fibrillation ( 29892015) Eosinophil counts ( 32888494 27863252) Erectile dysfunction ( 30583798) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: PIH1D1 PRDX2 SLC4A1 SLC4A3 SLC4A4 XPO1	89 interacting genes: ABL1 ACTN3 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CA4 CCND1 CDC25A CDC42 CDCA4 CDKN1B CHAC2 CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DNAJB11 DR1 E2F4 E2F5 EFEMP1 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 LINC01554 MAPK6 MSH6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 OGT ORC1 PHAX PHB PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SAMHD1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMR3B SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO1 SUMO2 TERF2IP TERT TOP2A TOP2B TP53 TP73
Entrez ID		762	7514
HPRD ID		00261	03975
Ensembl ID		ENSG00000167434	ENSG00000082898
Uniprot IDs		P22748	A0A7I2V2Y6 A0A7I2V461 A0A7I2V6B9 B3KWD0 O14980
PDB IDs		1ZNC 3F7B 3F7U 3FW3 5IPZ 5JN8 5JN9 5JNA 5JNC 5KU6	1W9C 2L1L 3GB8 4BSM 4BSN 5DIS 6TVO
Enriched GO Terms of Interacting Partners?
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