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XPO1 and NPM1
Number of citations of the paper that reports this interaction (PubMedID
16041368
)
105
Data Source:
BioGRID
(unspecified method)
HPRD
(in vivo)
XPO1
NPM1
Description
exportin 1
nucleophosmin 1
Image
GO Annotations
Cellular Component
Kinetochore
Nucleus
Nuclear Envelope
Annulate Lamellae
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cajal Body
Membrane
Nuclear Membrane
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Ribonucleoprotein Complex
Granular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Focal Adhesion
Large Ribosomal Subunit
Small Ribosomal Subunit
Membrane
Nuclear Speck
Spindle Pole Centrosome
Protein-containing Complex
Protein-DNA Complex
Ribonucleoprotein Complex
Molecular Function
RNA Binding
Nuclear Export Signal Receptor Activity
Protein Binding
Protein Domain Specific Binding
Small GTPase Binding
Core Promoter Sequence-specific DNA Binding
Chromatin Binding
Transcription Coactivator Activity
RNA Binding
Protein Kinase Inhibitor Activity
Protein Binding
RRNA Binding
Protein Kinase Binding
Tat Protein Binding
Histone Binding
Protein Homodimerization Activity
Ribosomal Large Subunit Binding
Ribosomal Small Subunit Binding
Protein N-terminus Binding
NF-kappaB Binding
Unfolded Protein Binding
DNA-binding Transcription Factor Binding
Biological Process
Ribosomal Subunit Export From Nucleus
Ribosomal Large Subunit Export From Nucleus
Ribosomal Small Subunit Export From Nucleus
Negative Regulation Of Transcription By RNA Polymerase II
Protein Export From Nucleus
Nucleocytoplasmic Transport
Response To Xenobiotic Stimulus
Regulation Of Centrosome Duplication
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Ribosome Biogenesis
Regulation Of Protein Export From Nucleus
MRNA Transport
Ribosomal Large Subunit Export From Nucleus
Ribosomal Small Subunit Export From Nucleus
Regulation Of Cell Growth
DNA Repair
Nucleosome Assembly
Chromatin Remodeling
RRNA Export From Nucleus
Cell Volume Homeostasis
Intracellular Protein Transport
Nucleocytoplasmic Transport
Centrosome Cycle
Signal Transduction
Cell Aging
Protein Localization
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Regulation Of Centrosome Duplication
Positive Regulation Of Centrosome Duplication
Negative Regulation Of Centrosome Duplication
Positive Regulation Of Protein Ubiquitination
Regulation Of Endodeoxyribonuclease Activity
Cellular Response To UV
Ribosome Assembly
Ribosomal Large Subunit Biogenesis
Ribosomal Small Subunit Biogenesis
Negative Regulation Of Apoptotic Process
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation
Positive Regulation Of Translation
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Centriole Replication
Negative Regulation Of MRNA Splicing, Via Spliceosome
Protein Stabilization
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Endoribonuclease Activity
Regulation Of EIF2 Alpha Phosphorylation By DsRNA
Regulation Of MRNA Stability Involved In Cellular Response To UV
Positive Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Protein Localization To Nucleolus
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Rev-mediated nuclear export of HIV RNA
NEP/NS2 Interacts with the Cellular Export Machinery
Downregulation of TGF-beta receptor signaling
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Deactivation of the beta-catenin transactivating complex
HuR (ELAVL1) binds and stabilizes mRNA
RHO GTPases Activate Formins
MAPK6/MAPK4 signaling
Mitotic Prometaphase
Cyclin A/B1/B2 associated events during G2/M transition
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
EML4 and NUDC in mitotic spindle formation
Heme signaling
Nuclear import of Rev protein
Nuclear import of Rev protein
SUMOylation of transcription cofactors
Deposition of new CENPA-containing nucleosomes at the centromere
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
ALK mutants bind TKIs
Signaling by ALK fusions and activated point mutants
Nuclear events stimulated by ALK signaling in cancer
Drugs
Selinexor
Artenimol
Diseases
GWAS
Atrial fibrillation (
29892015
)
Eosinophil counts (
32888494
27863252
)
Erectile dysfunction (
30583798
)
Mean reticulocyte volume (
32888494
)
Monocyte count (
32888494
)
Neutrophil count (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
28714469
)
Urinary sodium excretion (
31409800
)
White blood cell count (
32888494
)
Brain morphology (MOSTest) (
32665545
)
Height (
28552196
)
Multisite chronic pain (
33830993
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
89 interacting genes:
ABL1
ACTN3
ADAR
AGFG1
AHR
ANP32A
ANP32B
APC
ATF2
BECN1
BIRC5
BRCA2
CA4
CCND1
CDC25A
CDC42
CDCA4
CDKN1B
CHAC2
CHEK1
CHORDC1
CIITA
CRK
DDX3X
DESI1
DNAJB11
DR1
E2F4
E2F5
EFEMP1
EIF5A
ERF
FBXO7
FOXO4
HDAC3
HNF4A
HSPA9
HSPB1
IRF5
KIF17
LINC01554
MAPK6
MSH6
NF2
NMD3
NPM1
NUCB1
NUCB2
NUP153
NUP214
NUP50
NUP62
NXF3
NXT1
OGT
ORC1
PHAX
PHB
PKIA
RAD51
RAN
RANBP2
RANBP3
RCC1
RCN2
RGS14
RIC8A
RPS6KB1
SAMHD1
SERPINB1
SERTAD2
SIRT2
SMAD1
SMARCB1
SMR3B
SMURF1
SMURF2
SNUPN
SOX2
STAT1
STRADA
SUMO1
SUMO2
TERF2IP
TERT
TOP2A
TOP2B
TP53
TP73
65 interacting genes:
ABCC1
ACY1
ALK
APP
ARF1
CACYBP
CCR1
CD24
CDK1
CDK2
CDKN2A
CDT1
CENPW
CLK1
COX8A
CSNK2A1
DUX4
EIF2AK2
ELF4
EP300
ERG
ESR1
FBXW7
GADD45A
GNAI2
GNL3
GRB2
GZMM
H2AC20
H2BC21
H3-4
HAND2
HMGA1
HMGA2
HOXA7
IRF1
IRS1
LINC01554
MDM2
NCL
NOP2
NPM2
OGT
PADI4
PARP1
PLCG1
PLCG2
PLK1
PSMC4
RELA
RPGR
SENP3
SHC1
SIL1
SP1
SREK1
SUMO2
TCERG1
TFAP2A
TP53
TRIM28
UBC
UQCRH
XPO1
YY1
Entrez ID
7514
4869
HPRD ID
03975
01246
Ensembl ID
ENSG00000082898
ENSG00000181163
Uniprot IDs
A0A7I2V2Y6
A0A7I2V461
A0A7I2V6B9
B3KWD0
O14980
A0A0S2Z491
A0A0S2Z4G7
A0A140VJQ2
P06748
PDB IDs
1W9C
2L1L
3GB8
4BSM
4BSN
5DIS
6TVO
2LLH
2P1B
2VXD
5EHD
Enriched GO Terms of Interacting Partners
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