XPO1 and SIRT2

Number of citations of the paper that reports this interaction (PubMedID 26673895)
69

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		XPO1	SIRT2
Description		exportin 1	sirtuin 2
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Ribonucleoprotein Complex	Chromosome, Telomeric Region Heterochromatin Nucleus Chromatin Silencing Complex Chromosome Nucleolus Cytoplasm Centrosome Centriole Spindle Cytosol Microtubule Plasma Membrane Growth Cone Midbody Paranodal Junction Paranode Region Of Axon Perikaryon Myelin Sheath Lateral Loop Schmidt-Lanterman Incisure Juxtaparanode Region Of Axon Perinuclear Region Of Cytoplasm Mitotic Spindle Meiotic Spindle Glial Cell Projection
	Molecular Function	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding Protein Domain Specific Binding Small GTPase Binding	Chromatin Binding NAD+ ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Protein Deacetylase Activity NAD-dependent Protein Deacetylase Activity Histone Acetyltransferase Binding Histone Deacetylase Binding Tubulin Deacetylase Activity Ubiquitin Binding NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD+ Binding DNA-binding Transcription Factor Binding
	Biological Process	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II Protein Export From Nucleus Nucleocytoplasmic Transport Response To Xenobiotic Stimulus Regulation Of Centrosome Duplication Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Ribosome Biogenesis Regulation Of Protein Export From Nucleus MRNA Transport	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Assembly Protein ADP-ribosylation Protein Deacetylation Autophagy Mitotic Nuclear Membrane Reassembly Regulation Of Exit From Mitosis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Phosphatidylinositol 3-kinase Signaling Histone Deacetylation Substantia Nigra Development Myelination In Peripheral Nervous System Regulation Of Myelination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Peptidyl-lysine Deacetylation Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Protein Catabolic Process Regulation Of Phosphorylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Protein Kinase B Signaling Cellular Lipid Catabolic Process Innate Immune Response Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Signaling Pathway Cell Division Meiotic Cell Cycle Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Caloric Restriction Negative Regulation Of Oligodendrocyte Progenitor Proliferation Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Molecule Of Bacterial Origin Cellular Response To Hypoxia Cellular Response To Epinephrine Stimulus Tubulin Deacetylation Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Oocyte Maturation Negative Regulation Of Defense Response To Bacterium Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation Heme signaling	Initiation of Nuclear Envelope (NE) Reformation
Drugs		Selinexor	Cambinol
Diseases
GWAS		Atrial fibrillation ( 29892015) Eosinophil counts ( 32888494 27863252) Erectile dysfunction ( 30583798) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800) White blood cell count ( 32888494)
Interacting Genes		89 interacting genes: ABL1 ACTN3 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CA4 CCND1 CDC25A CDC42 CDCA4 CDKN1B CHAC2 CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DNAJB11 DR1 E2F4 E2F5 EFEMP1 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 LINC01554 MAPK6 MSH6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 OGT ORC1 PHAX PHB PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SAMHD1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMR3B SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO1 SUMO2 TERF2IP TERT TOP2A TOP2B TP53 TP73	20 interacting genes: ARHGDIA CDC14B CDC20 CDK2 EP300 FZR1 H3C1 HDAC6 HIF1A HOXA10 KAT2A KAT2B MDM2 OXTR PHGDH PLA2G4A RAD51 SP140 TUBA4A XPO1
Entrez ID		7514	22933
HPRD ID		03975	10377
Ensembl ID		ENSG00000082898	ENSG00000068903
Uniprot IDs		A0A7I2V2Y6 A0A7I2V461 A0A7I2V6B9 B3KWD0 O14980	A0A024R0G8 A0A0A0MRF5 Q8IXJ6
PDB IDs		1W9C 2L1L 3GB8 4BSM 4BSN 5DIS 6TVO	1J8F 3ZGO 3ZGV 4L3O 4R8M 4RMG 4RMH 4RMI 4RMJ 4X3O 4X3P 4Y6L 4Y6O 4Y6Q 5D7O 5D7P 5D7Q 5DY4 5DY5 5FYQ 5G4C 5MAR 5MAT 5Y0Z 5Y5N 5YQL 5YQM 5YQN 5YQO 6L65 6L66 6NR0 6QCN
Enriched GO Terms of Interacting Partners?
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