TMEM50B and CYP27B1

		TMEM50B	CYP27B1
Description		transmembrane protein 50B	cytochrome P450 family 27 subfamily B member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane	Cytoplasm Mitochondrion Mitochondrial Outer Membrane
	Molecular Function	Molecular_function Protein Binding	Calcidiol 1-monooxygenase Activity Iron Ion Binding Heme Binding Secalciferol 1-monooxygenase Activity
	Biological Process	Biological_process Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway	Vitamin Metabolic Process Calcium Ion Transport Negative Regulation Of Cell Population Proliferation Negative Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D 24-hydroxylase Activity Bone Mineralization Negative Regulation Of Cell Growth Regulation Of Bone Mineralization Response To Lipopolysaccharide Response To Vitamin D Response To Interferon-gamma Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Vitamin D Catabolic Process Response To Estrogen Positive Regulation Of Keratinocyte Differentiation Decidualization Calcium Ion Homeostasis G1 To G0 Transition Positive Regulation Of Vitamin D Receptor Signaling Pathway
Pathways			Vitamin D (calciferol) metabolism Vitamins Defective CYP27B1 causes VDDR1A
Drugs			Alfacalcidol
Diseases
GWAS		Crohn's disease ( 23128233) Educational attainment ( 25201988)	Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 19525955 21833088)
Interacting Genes		22 interacting genes: AMIGO1 BCL2L1 CLRN1 CREB3L1 CYP27B1 EDA FAM209A FXYD3 GPR152 GPX8 HLA-DPA1 LEPROTL1 LHFPL5 NCR1 SCN3B SLC10A6 SLC16A13 SLC35C2 TMEM14B TMEM52B TMEM88 TMX2	8 interacting genes: ATF2 HOXC10 ITGB7 MARS1 MYL6 SMC3 TMEM50B TUT4
Entrez ID		757	1594
HPRD ID		10747	02031
Ensembl ID		ENSG00000142188	ENSG00000111012
Uniprot IDs		P56557	O15528
PDB IDs
Enriched GO Terms of Interacting Partners?
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