ZFPL1 and CD3E

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ZFPL1	CD3E
Description		zinc finger protein like 1	CD3e molecule
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Golgi Apparatus Integral Component Of Membrane	Immunological Synapse Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Dendritic Spine Cell Body
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding	Transmembrane Signaling Receptor Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription, DNA-templated Vesicle-mediated Transport	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Positive Regulation Of T Cell Anergy Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly G Protein-coupled Receptor Signaling Pathway Response To Nutrient Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Cerebellum Development T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Protein-containing Complex Assembly Apoptotic Signaling Pathway
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling
Drugs			Muromonab Catumaxomab
Diseases
GWAS			Lung cancer in ever smokers ( 28604730) Pulse pressure ( 27841878)
Interacting Genes		63 interacting genes: AHNAK2 ATP5MF BIK BSND CD3E CGRRF1 CLEC10A CLEC7A CPLX4 CREB3L1 CYBRD1 EBP ELOVL4 ERGIC3 FAM209A FATE1 FKBP7 FKBP8 FNDC9 FRMD3 GORAB GPR42 HIBADH KASH5 KLRC1 LDLRAD1 LEUTX LIME1 LINC00839 MFF MFSD14B MGST3 MIP MRM3 MRPS18B MS4A3 MTERF3 PGRMC2 PLEKHO1 PVR RELL2 SCN3B SGMS2 SHISAL1 SLC10A6 SLC19A3 SLC7A14 SMIM3 SSMEM1 STX1A STX2 STX4 SYAP1 SYT1 TEX29 TM4SF19 TMEM106C TMEM139 TMEM14B TMEM237 TMEM31 TMPRSS2 TSTD2	28 interacting genes: ADAM33 BNIP3 CD3D CD3G CD79B CSK DRD2 EPS8L1 LCK MUC15 NAT8 NCK1 NCK2 NCL PIK3R1 PKMYT1 POLR1G PTPN22 SHC1 SNTA1 SYK TOP2B TRAT1 TRB UBASH3A UNC119 ZAP70 ZFPL1
Entrez ID		7542	916
HPRD ID		15729	08923
Ensembl ID		ENSG00000162300	ENSG00000198851
Uniprot IDs		A0A024R576 O95159	P07766
PDB IDs			1A81 1SY6 1XIW 2ROL 5QU2 6JXR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?