NPM1 and SP1

Number of citations of the paper that reports this interaction (PubMedID 19074833)
15

Data Source:
BioGRID (two hybrid)

		NPM1	SP1
Description		nucleophosmin 1	Sp1 transcription factor
Image
GO Annotations	Cellular Component	Granular Component Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Large Ribosomal Subunit Small Ribosomal Subunit Membrane Nuclear Speck Spindle Pole Centrosome Protein-containing Complex Protein-DNA Complex Ribonucleoprotein Complex	Chromatin Euchromatin Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	Core Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding RRNA Binding Protein Kinase Binding Tat Protein Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Protein N-terminus Binding NF-kappaB Binding Unfolded Protein Binding DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Histone Acetyltransferase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding HMG Box Domain Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Regulation Of Cell Growth DNA Repair Nucleosome Assembly Chromatin Remodeling RRNA Export From Nucleus Cell Volume Homeostasis Intracellular Protein Transport Nucleocytoplasmic Transport Centrosome Cycle Signal Transduction Cell Aging Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Centrosome Duplication Positive Regulation Of Centrosome Duplication Negative Regulation Of Centrosome Duplication Positive Regulation Of Protein Ubiquitination Regulation Of Endodeoxyribonuclease Activity Cellular Response To UV Ribosome Assembly Ribosomal Large Subunit Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Apoptotic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centriole Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of MRNA Stability Involved In Cellular Response To UV Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Localization To Nucleolus	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Cellular Response To Insulin Stimulus Response To Hydroperoxide Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation By Host Of Viral Transcription Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Nuclear import of Rev protein Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer	PPARA activates gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Activation of gene expression by SREBF (SREBP) Oncogene Induced Senescence RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes Estrogen-dependent gene expression
Drugs		Artenimol
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Height ( 28552196) Multisite chronic pain ( 33830993) Subcortical volume (MOSTest) ( 32665545)	Apolipoprotein B levels ( 32203549) High light scatter reticulocyte count ( 32888494) Hypospadias (moderate to severe) ( 31856834) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 27863252) Parkinsonism in frontotemporal lobe dementia ( 29724592) Percentage gas trapping ( 26030696) Progressive supranuclear palsy ( 30089514) Red blood cell count ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		65 interacting genes: ABCC1 ACY1 ALK APP ARF1 CACYBP CCR1 CD24 CDK1 CDK2 CDKN2A CDT1 CENPW CLK1 COX8A CSNK2A1 DUX4 EIF2AK2 ELF4 EP300 ERG ESR1 FBXW7 GADD45A GNAI2 GNL3 GRB2 GZMM H2AC20 H2BC21 H3-4 HAND2 HMGA1 HMGA2 HOXA7 IRF1 IRS1 LINC01554 MDM2 NCL NOP2 NPM2 OGT PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SIL1 SP1 SREK1 SUMO2 TCERG1 TFAP2A TP53 TRIM28 UBC UQCRH XPO1 YY1	152 interacting genes: AATF AHR AKT1 AR ARHGAP21 ARNT ATF7IP ATF7IP2 BCL11B BCL6 BCOR BRCA1 CASP3 CASP6 CASP7 CBX5 CCNA1 CCNA2 CCND1 CD2 CDK1 CDK2 CEBPB CSNK2A1 CTCFL CTNNB1 DDX5 DROSHA E2F1 E2F2 E2F3 EGR1 ELF1 ENDOU EP300 ESR1 ESR2 ESRRA ESRRB ESRRG ETS1 GABPA GATA1 GATA3 GATA4 GRIN1 HBZ HCFC1 HDAC1 HDAC2 HIF1A HINT1 HLTF HMGA1 HNF4A HNRNPA1 HOXC11 HSPA8 HTT IL1B JUN KIF1A KLF10 KLF4 KLF6 LDB1 LMO2 MAPK1 MAPK3 MAPK8 MBD1 MEF2C MEF2D MIER1 MIS18BP1 MSX1 MTREX MYC MYCN MYOD1 MYOG NAP1L1 NCOR1 NCOR2 NEDD4L NEPRO NFKB1 NFKB2 NFYA NFYB NFYC NKX3-1 NOS3 NPM1 NR2F1 NR5A1 NUP62 OGT PARP1 PER3 PML POGZ POU2F1 PPIG PPP1R13L PRKCZ PRKDC PSIP1 PSMC5 PURA RAPGEF3 RARA RB1 RBBP4 RBL1 REG1A REL RELA RNF4 RORA RXRA SENP6 SF3A1 SHC1 SMAD2 SMAD3 SMAD4 SMARCC1 SMARCC2 SOX10 SOX8 SP3 SP4 SREBF1 SREBF2 SRF SUB1 SUMO2 TAF4 TAL1 TBP TLX3 TP53 TP73 TPI1 USP39 VEGFA VHL YY1 ZBTB16 ZBTB2 ZBTB7A
Entrez ID		4869	6667
HPRD ID		01246	01796
Ensembl ID		ENSG00000181163	ENSG00000185591
Uniprot IDs		A0A0S2Z491 A0A0S2Z4G7 A0A140VJQ2 P06748	P08047
PDB IDs		2LLH 2P1B 2VXD 5EHD	1SP1 1SP2 1VA1 1VA2 1VA3 6PV0 6PV1 6PV2 6PV3 6UCO 6UCP
Enriched GO Terms of Interacting Partners?
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