VAV2 and STK24

Number of citations of the paper that reports this interaction (PubMedID 18654987)
21

Data Source:
BioGRID (two hybrid)

		VAV2	STK24
Description		vav guanine nucleotide exchange factor 2	serine/threonine kinase 24
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Membrane Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Angiogenesis Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Cell Size Cell Migration Lamellipodium Assembly Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction	Protein Phosphorylation Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Starvation Negative Regulation Of Cell Migration Response To Hydrogen Peroxide Protein Autophosphorylation Regulation Of Axon Regeneration Execution Phase Of Apoptosis
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Apoptotic cleavage of cellular proteins Apoptotic execution phase
Drugs			Fostamatinib
Diseases
GWAS		Central corneal thickness ( 29760442) Corneal astigmatism ( 30306274) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Multiple sclerosis ( 20598377) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) vWF and FVIII levels ( 21810271)	Adult body size ( 32376654) Adventurousness ( 30643258) Alzheimer's disease ( 22159054) Educational attainment ( 25201988 23722424) Gastroesophageal reflux disease ( 34187846) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Longevity ( 20834067) Methadone dose in opioid dependence ( 28115739) Mood instability ( 31168069) Reading disability or specific language impairment (pleiotropy) ( 25065397) Shoulder impingement or rotator cuff tear ( 33482370) Triglyceride levels ( 32203549) Urinary sodium excretion ( 31409800)
Interacting Genes		70 interacting genes: AR ARIH1 BIRC6 BOD1L1 BRDT BZW1 CAV1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CIZ1 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 ERBB4 FNTA FUCA1 FYN GAB1 GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MED21 MET MRGBP NCKAP5 NEK3 NUP214 PHF10 PNMA1 POGZ PPM1B PRLR PRRG4 RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 STOM SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1	12 interacting genes: CAB39 CASP3 CASP7 CASP8 ERBB2 LRRK2 NEDD4 OGT PDCD10 STK11 STK38L VAV2
Entrez ID		7410	8428
HPRD ID		02694	10385
Ensembl ID		ENSG00000160293	ENSG00000102572
Uniprot IDs		P52735	B4DR80 Q5U0E6 Q6P0Y1 Q9Y6E0
PDB IDs		2DLZ 2DM1 2LNW 2LNX 4ROJ	3A7F 3A7G 3A7H 3A7I 3A7J 3CKW 3CKX 3ZHP 4O27 4QML 4QMM 4QMN 4QMO 4QMP 4QMQ 4QMS 4QMT 4QMU 4QMV 4QMW 4QMX 4QMY 4QMZ 4QNA 4QO9 4U8Z 4W8D 4W8E 7B30 7B31 7B32 7B33 7B34 7B35
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?