VAV2 and ARIH1

Number of citations of the paper that reports this interaction (PubMedID 18654987)
21

Data Source:
BioGRID (two hybrid)

		VAV2	ARIH1
Description		vav guanine nucleotide exchange factor 2	ariadne RBR E3 ubiquitin protein ligase 1
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Cajal Body Nuclear Body Lewy Body
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Angiogenesis Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Cell Size Cell Migration Lamellipodium Assembly Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	ISG15 antiviral mechanism
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442) Corneal astigmatism ( 30306274) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Multiple sclerosis ( 20598377) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) vWF and FVIII levels ( 21810271)
Interacting Genes		70 interacting genes: AR ARIH1 BIRC6 BOD1L1 BRDT BZW1 CAV1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CIZ1 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 ERBB4 FNTA FUCA1 FYN GAB1 GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MED21 MET MRGBP NCKAP5 NEK3 NUP214 PHF10 PNMA1 POGZ PPM1B PRLR PRRG4 RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 STOM SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1	18 interacting genes: CCNE1 CDKN1B CRY1 DCUN1D1 EIF4E2 HSPB1 PLD1 RBX1 SEC31A SPOP UBC UBE2D1 UBE2D3 UBE2E2 UBE2L3 UBE2L6 UBE2N VAV2
Entrez ID		7410	25820
HPRD ID		02694	05730
Ensembl ID		ENSG00000160293	ENSG00000166233
Uniprot IDs		P52735	Q9Y4X5
PDB IDs		2DLZ 2DM1 2LNW 2LNX 4ROJ	1WD2 2M9Y 4KBL 4KC9 5TTE 5UDH 7B5L 7B5M 7B5N 7B5S
Enriched GO Terms of Interacting Partners?
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