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TRAF2 and MAP3K8
Number of citations of the paper that reports this interaction (PubMedID
11932422
)
18
Data Source:
HPRD
(in vivo)
TRAF2
MAP3K8
Description
TNF receptor associated factor 2
mitogen-activated protein kinase kinase kinase 8
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Tumor Necrosis Factor Receptor Superfamily Complex
Nucleoplasm
Cytosol
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Vesicle Membrane
CD40 Receptor Complex
Membrane Raft
TRAF2-GSTP1 Complex
Plasma Membrane Signaling Receptor Complex
IRE1-TRAF2-ASK1 Complex
Cytosol
Molecular Function
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
CD40 Receptor Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein-macromolecule Adaptor Activity
Mitogen-activated Protein Kinase Kinase Kinase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Identical Protein Binding
Tumor Necrosis Factor Binding
Protein-containing Complex Binding
Sphingolipid Binding
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Biological Process
Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Cytokine Production
Signal Transduction
Activation Of NF-kappaB-inducing Kinase Activity
Signal Transduction Involved In Regulation Of Gene Expression
Protein Catabolic Process
Positive Regulation Of Interleukin-2 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Glial Cell Apoptotic Process
Cellular Protein-containing Complex Assembly
Response To Endoplasmic Reticulum Stress
Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein-containing Complex Assembly
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of JNK Cascade
MRNA Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Protein-containing Complex Assembly
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Protein K63-linked Ubiquitination
Cellular Response To Nitric Oxide
Programmed Necrotic Cell Death
Interleukin-17-mediated Signaling Pathway
Negative Regulation Of Neuron Death
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of I-kappaB Phosphorylation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
MAPK Cascade
Protein Phosphorylation
Cell Cycle
T Cell Costimulation
Pathways
Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
Dimerization of procaspase-8
TNF signaling
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
Defective RIPK1-mediated regulated necrosis
CD28 dependent PI3K/Akt signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS
Platelet distribution width (
32888494
)
Asthma (
32296059
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
23128233
)
Systemising (
31508503
)
Ulcerative colitis (
28067908
)
Interacting Genes
380 interacting genes:
AASDHPPT
ABLIM1
ACTN3
AFF4
AGR2
AIMP2
AKR1B15
ALPL
AMOTL2
ANKRD11
ANKRD36BP1
APEX2
APPL1
AQP1
ARHGEF6
ARNT2
ARSJ
ASCC1
ATXN1
ATXN7
AXIN1
BAHD1
BANP
BAZ2B
BCL10
BCL6
BEX2
BEX3
BIRC2
BIRC3
BOD1L2
BYSL
C22orf15
C2CD6
CALCOCO2
CAPN15
CASP8
CASP8AP2
CATSPER1
CAV1
CBX8
CCDC187
CCDC198
CCDC33
CCHCR1
CCNJL
CD27
CD40
CDC20B
CDC37
CDC42
CDCA3
CDK18
CDK9
CDKN1B
CEP57L1
CFAP57
CFLAR
CHCHD2
CHMP2B
CHUK
CREB5
CRY1
CRY2
CRYBA2
CTCF
CWF19L2
CYB5R2
CYLD
DDI1
DDX6
DGCR6
DLGAP5
DMTN
DTNB
DVL2
DVL3
EAF1
EBF2
EDAR
EDARADD
EFEMP1
EFHC1
EGFR
EIF4G1
ELOA2
ENKD1
EP300
EP400
ERN1
ETV6
EWSR1
EXOC3-AS1
FADD
FAM107A
FAM120B
FAM124B
FAM161A
FAM161B
FAM214B
FAM50B
FAM90A1
FAM9A
FARS2
FATE1
FBF1
FBXO28
FDXACB1
FLNA
FLYWCH1
FNDC11
FNDC3B
FOXN1
FXR1
FXR2
GABPB1
GAS8
GCA
GCKR
GEM
GORASP2
GPANK1
GPKOW
GRIPAP1
GSE1
GSG1
GSTP1
GSTZ1
HENMT1
HINFP
HIVEP3
HOXA1
HOXB5
HSPA12B
IKBKB
IL15RA
IMPDH2
INO80B
IP6K3
IPO11
IQUB
IRF4
ITPK1
ITPRIPL1
JUN
KANK2
KANSL1
KIAA0408
KIAA1217
KIF26B
KIFC3
KLF3
LENG1
LINC02875
LNX1
LNX2
LONRF1
LRRK2
LTBR
LYSMD1
LZTS2
MACROH2A1
MALT1
MAP3K1
MAP3K14
MAP3K5
MAP3K8
MAP4K2
MAP4K5
MAPK9
MAPRE1
MAST2
MBLAC1
METTL13
MFAP1
MISP
MKRN3
MORN3
MOS
MPP3
MSRB2
MVP
MYO15B
NAB2
NATD1
NCAPH2
NEBL
NECAP2
NEDD9
NEK6
NFIL3
NFKBID
NGFR
NHSL2
NIF3L1
NMUR2
NOXA1
NR2C2
NR4A1
NRF1
NRIP1
NUDT16L1
NUDT18
PACS2
PALS1
PCGF2
PCGF5
PDLIM7
PDZD4
PEG3
PGBD1
PIAS2
PIBF1
PIN1
PKN1
POLR3C
POM121
PPL
PPP1R18
PPP1R32
PRKAB2
PRKRIP1
PRPF18
PSMB1
PSMD9
PSME3IP1
PSMF1
QARS1
QRICH1
RAD23A
RAD54L2
RALBP1
RANBP3
RAPGEF4
RASSF5
RBM41
RCOR3
RFX3
RGS14
RIBC2
RIN1
RIPK1
RIPK2
RIPK3
RIPPLY1
RIPPLY3
RNF146
RNF4
RRAS2
RSPH14
SAMD11
SCNM1
SETD5
SH2D4A
SHC3
SIAH2
SMG9
SMURF2
SNAI1
SNRNP25
SOX13
SOX30
SOX5
SOX9
SPATA2
SPG21
SPHK1
SPRY2
SUMO1
SUMO1P1
SYT17
TAB1
TAB2
TAB3
TANK
TAOK3
TBK1
TCAF1
TCEA2
TCEANC
TCL1A
TDP2
TEKT3
THAP7
THOP1
TICAM1
TIFA
TIGD4
TLE5
TNF
TNFAIP3
TNFRSF11A
TNFRSF12A
TNFRSF13B
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF25
TNFRSF4
TNFRSF8
TNFRSF9
TNFSF4
TNFSF9
TNIK
TRADD
TRAF1
TRAF3
TRAF3IP2
TRAF5
TRAF6
TRAIP
TRIM14
TRIM31
TRIM37
TRIM42
TRIM50
TROAP
TRPC4AP
TRPT1
TSC1
TSGA10IP
TSHZ2
TSHZ3
TSSC4
TTC23
TXN
UBC
UBE2D1
UBE2D2
UBE2I
UBE2N
UBE2V1
UBE2V2
UBQLN4
UBXN11
USF1
USP2
USP4
USP53
USP7
UTP14C
UTP23
VEZF1
VWA2
WASF1
YES1
YJU2B
ZBTB16
ZBTB24
ZBTB25
ZBTB43
ZBTB49
ZC2HC1C
ZFAND6
ZKSCAN3
ZMAT2
ZMYM5
ZNF205
ZNF250
ZNF35
ZNF410
ZNF417
ZNF438
ZNF488
ZNF544
ZNF572
ZNF574
ZNF646
ZNF648
ZNF655
ZNF662
ZNF688
ZNF774
ZSCAN23
ZSCAN32
ZSWIM3
ZZZ3
26 interacting genes:
ACP6
ACY3
ADAM10
AKT1
BMPR2
CD40
CHUK
GAD2
JCAD
LYZL2
MAP2K1
MAP2K4
MAP3K14
MTPAP
NFKB1
NFKB2
PARD3
PDK2
RANGAP1
REL
RELA
RIPK1
STIP1
TNIP2
TRAF2
TRAF6
Entrez ID
7186
1326
HPRD ID
03538
01863
Ensembl ID
ENSG00000127191
ENSG00000107968
Uniprot IDs
A0A024R8H5
Q12933
P41279
Q6FG25
PDB IDs
1CA4
1CA9
1CZY
1CZZ
1D00
1D01
1D0A
1D0J
1F3V
1QSC
3KNV
3M06
3M0A
3M0D
4Y83
4Y85
5IU2
Enriched GO Terms of Interacting Partners
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