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MAP3K8 and BMPR2
Number of citations of the paper that reports this interaction (PubMedID
15188402
)
32
Data Source:
HPRD
(in vitro)
MAP3K8
BMPR2
Description
mitogen-activated protein kinase kinase kinase 8
bone morphogenetic protein receptor type 2
Image
GO Annotations
Cellular Component
Cytosol
Extracellular Space
Nucleoplasm
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
Clathrin-coated Pit
Adherens Junction
Basal Plasma Membrane
Cell Surface
Postsynaptic Density
Apical Plasma Membrane
Dendrite
Neuronal Cell Body
Receptor Complex
Spanning Component Of Plasma Membrane
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Protein Binding
ATP Binding
Activin Receptor Activity, Type II
Phosphatase Activator Activity
Growth Factor Binding
Signaling Receptor Activator Activity
BMP Binding
Protein Serine/threonine Kinase Activator Activity
Cadherin Binding
Metal Ion Binding
BMP Receptor Activity
Transcription Regulator Activator Activity
Protein Tyrosine Kinase Binding
Biological Process
MAPK Cascade
Protein Phosphorylation
Cell Cycle
T Cell Costimulation
Blood Vessel Development
Osteoblast Differentiation
Mesoderm Formation
Maternal Placenta Development
Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Lymphangiogenesis
Blood Vessel Remodeling
Chondrocyte Development
Negative Regulation Of Systemic Arterial Blood Pressure
Outflow Tract Septum Morphogenesis
Outflow Tract Morphogenesis
Aortic Valve Development
Pulmonary Valve Development
Atrioventricular Valve Morphogenesis
Mitral Valve Morphogenesis
Tricuspid Valve Morphogenesis
Endocardial Cushion Development
Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Protein Phosphorylation
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Brain Development
Cellular Response To Starvation
Anterior/posterior Pattern Specification
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Lung Blood Pressure
Proteoglycan Biosynthetic Process
Negative Regulation Of Cell Growth
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Activin Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Ossification
Negative Regulation Of Vasoconstriction
Positive Regulation Of Transcription By RNA Polymerase II
Lung Alveolus Development
Negative Regulation Of Smooth Muscle Cell Proliferation
Cardiac Muscle Tissue Development
Positive Regulation Of Axon Extension Involved In Axon Guidance
Negative Regulation Of Muscle Cell Differentiation
Limb Development
Endochondral Bone Morphogenesis
Positive Regulation Of SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Atrial Septum Morphogenesis
Lymphatic Endothelial Cell Differentiation
Artery Development
Venous Blood Vessel Development
Positive Regulation Of Cartilage Development
Retina Vasculature Development In Camera-type Eye
Pharyngeal Arch Artery Morphogenesis
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Positive Regulation Of Protein Serine/threonine Kinase Activity
Endothelial Cell Apoptotic Process
Negative Regulation Of Chondrocyte Proliferation
Semi-lunar Valve Development
Negative Regulation Of DNA Biosynthetic Process
Pathways
CD28 dependent PI3K/Akt signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Signaling by BMP
Drugs
Dibotermin alfa
Fostamatinib
Diseases
GWAS
Asthma (
32296059
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
23128233
)
Systemising (
31508503
)
Ulcerative colitis (
28067908
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Intelligence (MTAG) (
29326435
)
Mean corpuscular hemoglobin (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
PR interval (
32439900
)
Reticulocyte fraction of red cells (
32888494
)
Triglyceride levels (
32203549
32154731
)
Urate levels (
23263486
)
Interacting Genes
26 interacting genes:
ACP6
ACY3
ADAM10
AKT1
BMPR2
CD40
CHUK
GAD2
JCAD
LYZL2
MAP2K1
MAP2K4
MAP3K14
MTPAP
NFKB1
NFKB2
PARD3
PDK2
RANGAP1
REL
RELA
RIPK1
STIP1
TNIP2
TRAF2
TRAF6
59 interacting genes:
ACTR8
ACVR1
ACVR1B
ARSA
BMP10
BMP2
BMP4
BMP6
BMP7
BMPR1A
BMPR1B
C4BPA
CASP10
CASP8
CCDC89
CES1
CHRND
CRYAB
CTBP1
DYNLT1
ERBB4
FHL2
FOXL1
FRS3
GDF2
GDF5
GDF6
GDF9
HAT1
HNRNPR
IGFBP2
INHBB
LIMK1
LMX1A
LSM10
LSP1
MAP3K8
MAPK8
MERTK
MOS
NBEA
NOP56
PDZRN3
PMPCA
PPP1CC
PRKCB
RAB11FIP1
RABGGTA
SMURF1
SULT1E1
TDGF1
TGFBR1
TOPBP1
TRIB3
TRPC1
TSR1
TUBB
TUBB4A
TWF1
Entrez ID
1326
659
HPRD ID
01863
02880
Ensembl ID
ENSG00000107968
ENSG00000204217
Uniprot IDs
P41279
Q6FG25
Q13873
PDB IDs
4Y83
4Y85
5IU2
2HLQ
3G2F
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Intersection)
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