MAP3K8 and JCAD

		MAP3K8	JCAD
Description		mitogen-activated protein kinase kinase kinase 8	junctional cadherin 5 associated
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Adherens Junction Ruffle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Cell Cycle T Cell Costimulation	Cell Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis
Pathways		CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)	Alcohol use disorder (total score) ( 30336701) Coronary artery disease ( 30104761 33020668) Intraocular pressure ( 29617998) Myocardial infarction ( 33532862)
Interacting Genes		26 interacting genes: ACP6 ACY3 ADAM10 AKT1 BMPR2 CD40 CHUK GAD2 JCAD LYZL2 MAP2K1 MAP2K4 MAP3K14 MTPAP NFKB1 NFKB2 PARD3 PDK2 RANGAP1 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	2 interacting genes: IL2RA MAP3K8
Entrez ID		1326	57608
HPRD ID		01863	13864
Ensembl ID		ENSG00000107968	ENSG00000165757
Uniprot IDs		P41279 Q6FG25	Q9P266
PDB IDs		4Y83 4Y85 5IU2
Enriched GO Terms of Interacting Partners?
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