ACTC1 and FSCN1

Number of citations of the paper that reports this interaction (PubMedID 12139639)
20

Data Source:
HPRD (in vivo)

		ACTC1	FSCN1
Description		actin alpha cardiac muscle 1	fascin actin-bundling protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Dynactin Complex Actin Filament Focal Adhesion Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Extracellular Exosome Blood Microparticle	Stress Fiber Ruffle Podosome Cytoplasm Cytosol Cytoskeleton Microvillus Cell-cell Junction Cell Cortex Actin Cytoskeleton Lamellipodium Filopodium Growth Cone Cell Projection Membrane Microspike Extracellular Exosome
	Molecular Function	Microfilament Motor Activity ATP Binding Myosin Binding	RNA Binding Actin Binding Protein Binding Protein-macromolecule Adaptor Activity Cadherin Binding Actin Filament Binding
	Biological Process	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration	Cell-cell Junction Assembly Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Lamellipodium Assembly Cell Migration Microspike Assembly Actin Cytoskeleton Organization Parallel Actin Filament Bundle Assembly Regulation Of Microvillus Assembly Regulation Of Actin Cytoskeleton Organization Establishment Of Apical/basal Cell Polarity Cell Motility Actin Filament Bundle Assembly Positive Regulation Of Filopodium Assembly Positive Regulation Of Podosome Assembly Positive Regulation Of Extracellular Matrix Disassembly
Pathways		Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle	Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
GWAS		Axial length ( 24144296) Refractive error ( 32231278 20835239)
Interacting Genes		42 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1	14 interacting genes: ACTA1 ACTC1 CTNNB1 DNAJB9 MAD1L1 MAPK8IP2 MYCBP2 NGFR OXTR PRKCA PRKCD RAB1A SMURF1 YWHAQ
Entrez ID		70	6624
HPRD ID		00015	04068
Ensembl ID		ENSG00000159251	ENSG00000075618
Uniprot IDs		B3KPP5 P68032	A0A384MEG1 B3KTA3 Q16658
PDB IDs			1DFC 3LLP 3P53 4GOV 4GOY 4GP0 4GP3 6B0T 6I0Z 6I10 6I11 6I12 6I13 6I14 6I15 6I16 6I17 6I18
Enriched GO Terms of Interacting Partners?
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