TCF12 and TRIM72

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		TCF12	TRIM72
Description		transcription factor 12	tripartite motif containing 72
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Regulator Complex	Cytoplasm Cytoplasmic Vesicle Membrane Sarcolemma
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding CAMP Response Element Binding BHLH Transcription Factor Binding SMAD Binding Protein Heterodimerization Activity E-box Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	Phosphatidylserine Binding Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Immune Response Nervous System Development Muscle Organ Development Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Plasma Membrane Repair Muscle System Process Exocytosis Muscle Organ Development Negative Regulation Of Myotube Differentiation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Protein Homooligomerization
Pathways		Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription NGF-stimulated transcription	Smooth Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062) Glaucoma (primary open-angle) ( 33627673 29891935) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494 27863252) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969)
Interacting Genes		86 interacting genes: ACTB ADAM10 ARL16 ARMC8 ASCL3 ASCL4 BCL2L10 BMERB1 BMF C1orf109 CDKN2C CFAP206 CKS1B CLCNKA CRCP CREBBP DDX6 DGCR6 EDRF1 EP300 EXOC8 FERD3L FIGLA FRMD6 GRB7 HAND1 HAND2 HEXIM2 HOPX ID1 ID2 ID3 LAMTOR5 LNX1 LYSMD1 MAPK6 MAPKBP1 MLLT6 MORN4 MSC MSGN1 MYF6 MYO15B NAGK NEK6 NEUROD1 NEUROG1 NEUROG3 NGLY1 NHLH2 OLIG3 OSGIN1 PIN1 PRKAB2 PRSS23 PSMA1 PTF1A QARS1 RBM8A RNASEL RSL24D1 RUNX1T1 SCG3 SLC12A1 SLC24A1 SOX10 SOX8 SPG21 SPTBN5 SRI STAT5A STK16 TAF4 TAL2 TBC1D21 TBP TCF21 TCF23 TCF3 TRIM72 TSNAX TWIST2 VPS28 WTAP YKT6 ZNF688	15 interacting genes: ABI2 C1orf216 INSR IRS1 MED21 MZT1 NMI PPP3CA SMARCD1 TCF12 TRIM32 UBE2I UBE2N VSIG4 ZNF655
Entrez ID		6938	493829
HPRD ID		02725	17412
Ensembl ID		ENSG00000140262	ENSG00000177238
Uniprot IDs		A0A024R5T1 A0A024R5Z0 F5GY10 Q99081	Q6ZMU5
PDB IDs		2KNH 4JOL	3KB5
Enriched GO Terms of Interacting Partners?
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