TCF12 and HEXIM2

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		TCF12	HEXIM2
Description		transcription factor 12	HEXIM P-TEFb complex subunit 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding CAMP Response Element Binding BHLH Transcription Factor Binding SMAD Binding Protein Heterodimerization Activity E-box Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Immune Response Nervous System Development Muscle Organ Development Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated
Pathways		Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062) Glaucoma (primary open-angle) ( 33627673 29891935) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494 27863252) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969)	Asthma ( 31959851 31619474) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)
Interacting Genes		86 interacting genes: ACTB ADAM10 ARL16 ARMC8 ASCL3 ASCL4 BCL2L10 BMERB1 BMF C1orf109 CDKN2C CFAP206 CKS1B CLCNKA CRCP CREBBP DDX6 DGCR6 EDRF1 EP300 EXOC8 FERD3L FIGLA FRMD6 GRB7 HAND1 HAND2 HEXIM2 HOPX ID1 ID2 ID3 LAMTOR5 LNX1 LYSMD1 MAPK6 MAPKBP1 MLLT6 MORN4 MSC MSGN1 MYF6 MYO15B NAGK NEK6 NEUROD1 NEUROG1 NEUROG3 NGLY1 NHLH2 OLIG3 OSGIN1 PIN1 PRKAB2 PRSS23 PSMA1 PTF1A QARS1 RBM8A RNASEL RSL24D1 RUNX1T1 SCG3 SLC12A1 SLC24A1 SOX10 SOX8 SPG21 SPTBN5 SRI STAT5A STK16 TAF4 TAL2 TBC1D21 TBP TCF21 TCF23 TCF3 TRIM72 TSNAX TWIST2 VPS28 WTAP YKT6 ZNF688	49 interacting genes: ADAMTSL4 AHCYL1 AP2M1 CACNB2 CCDC33 CCNT1 CDK9 CFP CTIF DBF4B EGFL7 FAM161A GAS8 GATA1 HEXIM1 HOXA1 HSF2BP IHO1 KPNA3 KPRP KRTAP13-3 LNX1 MEOX2 PICK1 PIM1 PIN1 PRDM14 PSMA1 RNPS1 SAXO1 SDCBP SPRED1 SPRY1 SPRY2 TADA3 TCF12 TERF1 TERF2 TLE5 TNFAIP1 TRIM14 YPEL3 ZNF250 ZNF426 ZNF500 ZNF558 ZNF655 ZNF699 ZNF789
Entrez ID		6938	124790
HPRD ID		02725	08129
Ensembl ID		ENSG00000140262	ENSG00000168517
Uniprot IDs		A0A024R5T1 A0A024R5Z0 F5GY10 Q99081	Q96MH2
PDB IDs		2KNH 4JOL
Enriched GO Terms of Interacting Partners?
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