TAF12 and ARID1A

		TAF12	ARID1A
Description		TATA-box binding protein associated factor 12	AT-rich interaction domain 1A
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GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFTC Complex SLIK (SAGA-like) Complex	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Brahma Complex NpBAF Complex NBAF Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Heterodimerization Activity DNA-binding Transcription Factor Binding	DNA Binding Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Nucleosome Binding
	Biological Process	DNA-templated Transcription, Initiation Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Histone H3 Acetylation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II Preinitiation Complex Assembly	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Intracellular Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Nucleosome Mobilization Glucocorticoid Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Chromatin-mediated Maintenance Of Transcription
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome HATs acetylate histones RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Type 2 diabetes ( 31049640)	Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549 28869591) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver volume ( 34128465) Metabolic syndrome ( 31589552) Monocyte percentage of white cells ( 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 33339817) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) White matter hyperintensities in ischemic stroke ( 26674333)
Interacting Genes		24 interacting genes: ARID1A ATF7 CPSF1 H3-4 MYC NFYA NFYB NFYC PRKAR2B TAF1 TAF10 TAF11 TAF15 TAF1A TAF2 TAF4 TAF4B TAF5 TAF6 TAF7 TAF8 TAF9 TBP UBE2I	24 interacting genes: CDC123 EDEM1 ESR1 EWSR1 FUS GATA1 GMEB1 HIC1 ITCH KLF1 MLLT1 NCOA1 NEDD4 PGR RARA RARB RARG SMARCA4 SMPDL3B TAF12 TAF15 THEMIS2 TP53 VPS41
Entrez ID		6883	8289
HPRD ID		15981	04319
Ensembl ID		ENSG00000120656	ENSG00000117713
Uniprot IDs		Q16514	O14497
PDB IDs		1H3O 6MZC 6MZD 6MZL 6MZM	1RYU 6LTH 6LTJ
Enriched GO Terms of Interacting Partners?
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