ARID1A and THEMIS2

		ARID1A	THEMIS2
Description		AT-rich interaction domain 1A	thymocyte selection associated family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Brahma Complex NpBAF Complex NBAF Complex	Nucleus Cytoplasm
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Nucleosome Binding	Protein Binding
	Biological Process	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Intracellular Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Nucleosome Mobilization Glucocorticoid Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Chromatin-mediated Maintenance Of Transcription	Inflammatory Response Cell Adhesion T Cell Receptor Signaling Pathway Regulation Of B Cell Activation
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549 28869591) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver volume ( 34128465) Metabolic syndrome ( 31589552) Monocyte percentage of white cells ( 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 33339817) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) White matter hyperintensities in ischemic stroke ( 26674333)	Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Waist-hip ratio ( 28552196) White blood cell count ( 32888494)
Interacting Genes		24 interacting genes: CDC123 EDEM1 ESR1 EWSR1 FUS GATA1 GMEB1 HIC1 ITCH KLF1 MLLT1 NCOA1 NEDD4 PGR RARA RARB RARG SMARCA4 SMPDL3B TAF12 TAF15 THEMIS2 TP53 VPS41	3 interacting genes: ARID1A HSPB2 NOTCH2NLA
Entrez ID		8289	9473
HPRD ID		04319	12728
Ensembl ID		ENSG00000117713	ENSG00000130775
Uniprot IDs		O14497	Q5TEJ8
PDB IDs		1RYU 6LTH 6LTJ
Enriched GO Terms of Interacting Partners?
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