TAF4 and JUN

Number of citations of the paper that reports this interaction (PubMedID 20557936)
10

Data Source:
BioGRID (pull down)

		TAF4	JUN
Description		TATA-box binding protein associated factor 4	Jun proto-oncogene, AP-1 transcription factor subunit
Image
GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Factor TFIID Complex Cytosol Protein-containing Complex Transcription Factor TFTC Complex MLL1 Complex	Nuclear Chromosome Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Plasma Membrane Transcription Factor AP-1 Complex
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Aryl Hydrocarbon Receptor Binding Protein Heterodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding GTPase Activator Activity Protein Binding Transcription Factor Binding Enzyme Binding Ubiquitin Protein Ligase Binding CAMP Response Element Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Ovarian Follicle Development DNA-templated Transcription, Initiation Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Release Of Cytochrome C From Mitochondria Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Ras Protein Signal Transduction Aging Learning Circadian Rhythm Response To Radiation Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Lipopolysaccharide Response To Cytokine Cellular Response To Reactive Oxygen Species Regulation Of Cell Population Proliferation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Neuron Apoptotic Process Negative Regulation By Host Of Viral Transcription Positive Regulation By Host Of Viral Transcription Positive Regulation Of Monocyte Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity Cellular Response To Potassium Ion Starvation Response To CAMP Regulation Of Cell Cycle Membrane Depolarization SMAD Protein Signal Transduction Cellular Response To Cadmium Ion Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of DNA-templated Transcription, Initiation
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling TP53 Regulates Transcription of DNA Repair Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression WNT5:FZD7-mediated leishmania damping
Drugs			Adapalene Vinblastine Pseudoephedrine Irbesartan Arsenic trioxide LGD-1550
Diseases
GWAS		Body mass index ( 28892062) Fasting glucose ( 33381925) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Systolic blood pressure ( 33230300)	Aspartate aminotransferase levels ( 33547301) Cognitive performance ( 19734545) Night sleep phenotypes ( 27126917)
Interacting Genes		22 interacting genes: AHR ATF7 CBX3 CBX5 CREM GTF2A1 GTF2A2 H3-4 HTT JUN SP1 TAF1 TAF10 TAF11 TAF12 TAF2 TAF5 TAF6 TAF7 TAF8 TAF9 TCF12	189 interacting genes: ABL1 AKAP5 APLP2 APP AR ARRB1 ATF1 ATF2 ATF3 ATF4 BATF BATF2 BBS7 BCL3 BCL6 BLM BRCA1 CASP9 CCND1 CEBPE CEBPG CLINT1 COP1 COPS5 CREB3 CREB5 CREBBP CSNK2A1 DAB1 DACH1 DDIT3 DDX21 DHX9 DNMT3L EDF1 EGR1 ELF3 ELOF1 EN1 EP300 EPAS1 ERG ESR1 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXW7 FOS FOSB FOSL1 FOSL2 GART GATA2 GOPC GPR18 GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HCFC1 HDAC3 HDAC9 HDGF HHEX HIF1A HMGA1 HNRNPM HOXA9 HOXC8 HSP90AA1 HSPA8 IKBKB IRAK1 ISCU ITCH ITPK1 JDP2 KLF5 KMT2C KPNA2 M6PR MACF1 MAF MAFB MAP2K4 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MAPRE3 MBD3 MDM2 MOK MTA1 MYBBP1A MYOD1 NACA NAT14 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEDD4 NELFB NFE2L1 NFE2L2 NFYA NFYC NR3C1 NR5A1 NRIP1 NTRK3 PACS1 PHOX2A PIAS1 PIAS2 PIN1 PML POU1F1 PPARG PPP3CB PPP4C PRKD1 PRKDC PRRC2A RB1 RBM39 RELA RNF187 ROR1 RPL18A RPS6KA2 RUNX1 RUNX2 SKI SMAD2 SMAD3 SMAD4 SMARCD1 SMARCD3 SNAPC5 SNIP1 SNRK SOX10 SOX8 SP1 SPI1 SPIB STAT1 STAT3 STAT4 STRN4 SUMO1 SUMO2 SUMO3 SUMO4 TACSTD2 TAF1 TAF4 TBP TCF20 TCF4 TDG TGIF1 TOP1 TOP2A TP53 TPM1 TPM2 TRAF2 TRIP4 TSC22D3 TSG101 UBB UBC UBE2I USP6 VAV1 VDR ZBTB7C
Entrez ID		6874	3725
HPRD ID		11797	01302
Ensembl ID		ENSG00000130699	ENSG00000177606
Uniprot IDs		O00268	P05412
PDB IDs		1H3O 2P6V 6MZC 6MZD 6MZL 6MZM	1A02 1FOS 1JNM 1JUN 1S9K 1T2K 5FV8 5T01 6Y3V
Enriched GO Terms of Interacting Partners?
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