CDKL5 and SPTBN4

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		CDKL5	SPTBN4
Description		cyclin dependent kinase like 5	spectrin beta, non-erythrocytic 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome Ruffle Membrane Dendrite Cytoplasm Ciliary Basal Body Dendritic Growth Cone Perinuclear Region Of Cytoplasm Ciliary Tip Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Adherens Junction Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Cell Junction Cortical Actin Cytoskeleton Node Of Ranvier Paranode Region Of Axon Cell Projection Neuronal Cell Body Axon Initial Segment Axon Hillock Extracellular Exosome Cell Body Fiber
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Small GTPase Binding Protein Serine Kinase Activity	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatase Binding Ankyrin Binding Spectrin Binding Actin Filament Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Neuron Migration Protein Phosphorylation Positive Regulation Of GTPase Activity Positive Regulation Of Axon Extension Protein Autophosphorylation Regulation Of Dendrite Development Positive Regulation Of Dendrite Morphogenesis Regulation Of Cell Cycle Positive Regulation Of Dendritic Spine Development Regulation Of Postsynapse Organization Regulation Of Cilium Assembly	Regulation Of Sodium Ion Transport Cytoskeleton Organization Axonogenesis Sensory Perception Of Sound Adult Walking Behavior Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Actin Cytoskeleton Organization Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Actin Filament Capping Cardiac Conduction Protein Localization To Plasma Membrane
Pathways			NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462)	Antibody level in response to infection ( 25758998) Carotid intima media thickness (mean) ( 31801372) Hemoglobin levels ( 32327693) Pulse pressure ( 30578418)
Interacting Genes		4 interacting genes: MLH1 SKIV2L SPTBN4 TACC3	16 interacting genes: ANK3 ARC CDC37 CDKL5 CELSR3 CENPU CLK1 DISC1 GADD45A GSK3B NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1
Entrez ID		6792	57731
HPRD ID		02190	09372
Ensembl ID		ENSG00000008086	ENSG00000160460
Uniprot IDs		O76039	Q9H254
PDB IDs		4BGQ
Enriched GO Terms of Interacting Partners?
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