SPTBN4 and PTPRN2

Number of citations of the paper that reports this interaction (PubMedID 11086001)
112

Data Source:
HPRD (two hybrid, in vivo)

		SPTBN4	PTPRN2
Description		spectrin beta, non-erythrocytic 4	protein tyrosine phosphatase receptor type N2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Adherens Junction Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Cell Junction Cortical Actin Cytoskeleton Node Of Ranvier Paranode Region Of Axon Cell Projection Neuronal Cell Body Axon Initial Segment Axon Hillock Extracellular Exosome Cell Body Fiber	Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Terminal Bouton Receptor Complex Ficolin-1-rich Granule Membrane
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatase Binding Ankyrin Binding Spectrin Binding Actin Filament Binding Cytoskeletal Protein-membrane Anchor Activity	Transmembrane Receptor Protein Tyrosine Phosphatase Activity
	Biological Process	Regulation Of Sodium Ion Transport Cytoskeleton Organization Axonogenesis Sensory Perception Of Sound Adult Walking Behavior Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Actin Cytoskeleton Organization Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Actin Filament Capping Cardiac Conduction Protein Localization To Plasma Membrane	Protein Dephosphorylation Lipid Metabolic Process Neurotransmitter Secretion Negative Regulation Of GTPase Activity Peptidyl-tyrosine Dephosphorylation Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	Neutrophil degranulation
Drugs
Diseases
GWAS		Antibody level in response to infection ( 25758998) Carotid intima media thickness (mean) ( 31801372) Hemoglobin levels ( 32327693) Pulse pressure ( 30578418)	Bipolar disorder and schizophrenia ( 21057379) Breast cancer in childhood cancer survivors ( 29059430) Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy ( 29059430) Calcium levels ( 25972035) Carotid plaque burden ( 28282560) Chronic rhinosinusitis ( 33393196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Diastolic blood pressure ( 27841878) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) Hearing loss in noise exposure ( 33242228) Inflammatory skin disease ( 25574825) Intelligence (MTAG) ( 29326435) Myopia (pathological) ( 23049088) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Obesity-related traits ( 23251661) Plasma anti-thyroid peroxidase levels ( 29678681) Refractive error ( 32231278) Response to amphetamines ( 22952603) Retinal detachment or retinal break ( 31816047) Serum metabolite concentrations in chronic kidney disease ( 29545352) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Triacylglyceride levels ( 31551469)
Interacting Genes		16 interacting genes: ANK3 ARC CDC37 CDKL5 CELSR3 CENPU CLK1 DISC1 GADD45A GSK3B NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1	4 interacting genes: CKAP5 RHEB SPTBN4 UBQLN4
Entrez ID		57731	5799
HPRD ID		09372	03413
Ensembl ID		ENSG00000160460	ENSG00000155093
Uniprot IDs		Q9H254	E7EM83 I6L9F8 Q92932
PDB IDs			2QEP 4HTI 4HTJ
Enriched GO Terms of Interacting Partners?
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