CDKL5 and TACC3

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		CDKL5	TACC3
Description		cyclin dependent kinase like 5	transforming acidic coiled-coil containing protein 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome Ruffle Membrane Dendrite Cytoplasm Ciliary Basal Body Dendritic Growth Cone Perinuclear Region Of Cytoplasm Ciliary Tip Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Spindle Pole Cytoplasm Cytosol Centriolar Satellite Intracellular Membrane-bounded Organelle Mitotic Spindle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Small GTPase Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Neuron Migration Protein Phosphorylation Positive Regulation Of GTPase Activity Positive Regulation Of Axon Extension Protein Autophosphorylation Regulation Of Dendrite Development Positive Regulation Of Dendrite Morphogenesis Regulation Of Cell Cycle Positive Regulation Of Dendritic Spine Development Regulation Of Postsynapse Organization Regulation Of Cilium Assembly	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Metaphase/anaphase Transition Of Mitotic Cell Cycle Cell Population Proliferation Cerebral Cortex Development Cell Division Regulation Of Mitotic Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis
Pathways			NOTCH3 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462)	Bladder cancer ( 24163127 20972438) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Mean spheric corpuscular volume ( 32888494) Subcortical volume (MOSTest) ( 32665545) Urinary bladder cancer ( 20348956)
Interacting Genes		4 interacting genes: MLH1 SKIV2L SPTBN4 TACC3	30 interacting genes: AKAP9 ARHGDIG ARNT ARNT2 ASPSCR1 AURKA BEX2 BEX3 C2CD6 CCHCR1 CDC20B CDKL5 CIB3 CLIP4 EIF3C GDF15 IQCD KAT2A KIZ KLC1 KLHL38 NDEL1 NOD2 NUP54 RNF20 SNX20 SPATA18 TBC1D22B TTF2 VPS37C
Entrez ID		6792	10460
HPRD ID		02190	05601
Ensembl ID		ENSG00000008086	ENSG00000013810
Uniprot IDs		O76039	Q9Y6A5
PDB IDs		4BGQ	5LXN 5LXO 5ODS 5ODT
Enriched GO Terms of Interacting Partners?
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