STAT4 and LY86

		STAT4	LY86
Description		signal transducer and activator of transcription 4	lymphocyte antigen 86
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytosol	Extracellular Space
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Defense Response Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II	Inflammatory Response Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response
Pathways		Interleukin-20 family signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-21 signaling	Toll Like Receptor 4 (TLR4) Cascade
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Behcet's disease ( 23001997 23291587) Celiac disease ( 22057235 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil counts ( 32888494) Gamma glutamyl transferase levels ( 29403010) Generalized epilepsy ( 30531953) Hepatocellular carcinoma in hepatitis B infection ( 23242368) Idiopathic inflammatory myopathy ( 26362759) Inflammatory bowel disease ( 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Limited cutaneous systemic scleroderma ( 29293537) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602) Nontyphoidal Salmonella bacteraemia ( 29523850) Primary biliary cholangitis ( 28425483 23000144 21399635 26394269) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 32723749 30423114 30572963 23143596 24390342 20453841 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) SjÃ¶gren's syndrome ( 24097066 24097067 28076899) Systemic lupus erythematosus ( 27399966 24871463 26606652 23273568 33272962 26663301 23053960 26316170 26502338 18204098 21408207 32771030 19165918 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 28314753 24387989 21750679 31672989 33069728 30572963 20383147 29293537 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 34127860) Vitiligo ( 27723757)	Chronic obstructive pulmonary disease ( 30804561) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder (broad) ( 20038947) Multiple sclerosis ( 31604244) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Serum uric acid levels ( 30993211) Systolic blood pressure ( 31134134) Systolic blood pressure (education interaction) ( 31134134) Urate levels in overweight individuals ( 25811787) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Waist-hip ratio ( 23563607 23966867 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		24 interacting genes: ADRB2 CADM3 CCDC85A CLPP CREBBP CRK DNAH7 HNRNPCP2 IL12RB1 IL12RB2 JUN LY86 MAP2K6 MAPK14 NABP1 NEMP2 NMI PIAS2 PTMS SH2D1B STAT1 STAT3 TMEFF2 ZNF467	4 interacting genes: APP CD180 GEMIN4 STAT4
Entrez ID		6775	9450
HPRD ID		02779	05578
Ensembl ID		ENSG00000138378	ENSG00000112799
Uniprot IDs		Q14765	O95711
PDB IDs			3B2D
Enriched GO Terms of Interacting Partners?
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