LY86 and GEMIN4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LY86	GEMIN4
Description		lymphocyte antigen 86	gem nuclear organelle associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Body Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Exosome Gemini Of Coiled Bodies
	Molecular Function	Protein Binding	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Inflammatory Response Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response	Spliceosomal SnRNP Assembly RRNA Processing
Pathways		Toll Like Receptor 4 (TLR4) Cascade	snRNP Assembly
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder (broad) ( 20038947) Multiple sclerosis ( 31604244) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Serum uric acid levels ( 30993211) Systolic blood pressure ( 31134134) Systolic blood pressure (education interaction) ( 31134134) Urate levels in overweight individuals ( 25811787) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Waist-hip ratio ( 23563607 23966867 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Prostate cancer ( 23535732)
Interacting Genes		4 interacting genes: APP CD180 GEMIN4 STAT4	55 interacting genes: AGO2 ALPP CALCOCO2 CCDC185 CCT3 CDC20B CERCAM CFP DDX20 DHX9 DMPK FBXL12 FLAD1 GEMIN5 GLYR1 HR KANK2 KARS1 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP2-3 KRTAP2-4 KRTAP9-2 LGALS1 LGALS3 LY86 MORC4 NPPB NUFIP1 PIAS3 PSMB1 PTCD1 PTEN RAD51D RN7SL1 RNU1-1 RNU2-1 S1PR4 SNRPB SNRPD1 SNRPD2 SPG21 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TAP1 TOP1 UFC1 USP15 USP2 ZNF326 ZNF35
Entrez ID		9450	50628
HPRD ID		05578	07370
Ensembl ID		ENSG00000112799	ENSG00000179409
Uniprot IDs		O95711	I3L2C7 P57678 Q8WUM5
PDB IDs		3B2D
Enriched GO Terms of Interacting Partners?
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