STAC and NCKIPSD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid, two hybrid)

		STAC	NCKIPSD
Description		SH3 and cysteine rich domain	NCK interacting protein with SH3 domain
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GO Annotations	Cellular Component	Cytosol T-tubule Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cytosol Intermediate Filament
	Molecular Function	Protein Binding Transmembrane Transporter Binding Metal Ion Binding	Protein Binding Cytoskeletal Protein Binding Myosin Binding SH3 Domain Binding Arp2/3 Complex Binding
	Biological Process	Skeletal Muscle Contraction Signal Transduction Cellular Response To Heat Intracellular Signal Transduction Positive Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cation Channel Activity	Endocytosis Cytoskeleton Organization Positive Regulation Of Neuron Projection Development
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Age-related cognitive decline (global cognition) (slope of z-scores) ( 30954325) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma ( 29273806) Brooding (response to stress) ( 30886212) Celiac disease ( 23936387) Erectile dysfunction in type 1 diabetes ( 22704111) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 31537649) Metabolite levels ( 23823483) Smoking behaviour (maximum cigarettes in a 24 hour period) ( 29532581)	Anorexia nervosa ( 31308545) Blood protein levels ( 28240269) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Myocardial infarction ( 33532862) Parkinson's disease ( 28892059) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		22 interacting genes: APP FBXO25 GOLGA2 KANK2 KIAA1958 LIMD1 LMNA LRRK2 LZTS2 MEOX2 NBPF19 NCKIPSD NEDD4L NOTCH2NLA PAX5 PAX6 PJA1 POU6F2 RNF208 STAT5B TRIP6 TRMO	42 interacting genes: ABI2 ARHGEF7 BAIAP2 CCDC187 CPNE2 CYSLTR2 DIAPH2 DIAPH3 DLG4 DMRTB1 ENKD1 FASLG GAS7 GRB2 HSPB1 ITGB1 KHDRBS1 LGALS4 MAPK3 MED25 NCK1 NCK2 PIN1 PKP2 POLR3C PRPF31 PSMD9 PSORS1C2 RBM22 RBP7 RXFP3 SHANK3 SNRPC SORBS3 STAC TSEN54 VEZF1 WAS WASL YWHAG ZBTB47 ZC2HC1C
Entrez ID		6769	51517
HPRD ID		11890	09450
Ensembl ID		ENSG00000144681	ENSG00000213672
Uniprot IDs		B4DR96 B4DZ13 E9PEA7 Q8WUK8 Q99469	Q9NZQ3
PDB IDs		2DL4 6B25	6DEC 6DED 6DEE
Enriched GO Terms of Interacting Partners?
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