Description |
SRC proto-oncogene, non-receptor tyrosine kinase |
protein tyrosine phosphatase non-receptor type 11 |
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GO Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
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- Alcohol consumption (max-drinks) ( 29460428)
- Alcohol dependence symptom count ( 29460428)
- Apolipoprotein A1 levels ( 32203549)
- Blood pressure ( 21572416)
- Body mass index ( 26426971)
- Diastolic blood pressure ( 26390057)
- Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
- Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
- Glycated hemoglobin levels ( 34059833)
- HDL cholesterol levels ( 32203549)
- Hematological parameters ( 19820697)
- Hip circumference adjusted for BMI ( 34021172)
- Hypothyroidism ( 22493691)
- Low HDL-cholesterol levels ( 31006500)
- Mean arterial pressure ( 27618448)
- Medication use (agents acting on the renin-angiotensin system) ( 31015401)
- Medication use (beta blocking agents) ( 31015401)
- Medication use (diuretics) ( 31015401)
- Medication use (thyroid preparations) ( 31015401)
- Multiple sclerosis ( 31604244)
- Peripheral artery disease ( 31285632)
- Platelet count ( 22139419 32888494)
- Reaction time ( 29844566)
- Response to alcohol consumption (flushing response) ( 29460428)
- Retinal vascular caliber ( 21060863)
- Rheumatoid arthritis ( 30423114 24390342)
- Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
- Systolic blood pressure ( 26390057 30578418)
- Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
- Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
- Tetralogy of Fallot ( 23297363)
- Type 1 diabetes ( 17554300)
- Urate levels ( 23263486)
- Waist-to-hip ratio adjusted for BMI ( 34054925)
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Interacting Genes |
310 interacting genes:
ABL1
ACTN1
ADAM12
ADAM15
ADRB2
ADRB3
AFAP1
AFAP1L2
AGAP1
AKT1
ALDOB
ANKRD11
ANXA1
ANXA2
ANXA7
AR
ARHGAP1
ARHGAP17
ARHGAP32
ARHGAP35
ARR3
ASAP1
ATG9A
ATP2B4
AXL
BAAT
BARD1
BCAR1
BCCIP
BCR
BMX
CA3
CASP8
CAV1
CAV2
CBL
CBLC
CCDC180
CCNA1
CD2AP
CD33
CD36
CD44
CD46
CD59
CDC25A
CDC37
CDCP1
CDH5
CDK1
CDK5
CDKN1B
CEACAM1
CEACAM3
CFL1
CHUK
CLTC
CNTNAP1
COASY
CORO7
CRMP1
CSK
CTNNB1
CTNND1
CTSV
CTTN
CUL4B
DAB1
DAB2
DAG1
DAPP1
DDR2
DGKA
DGKZ
DLG4
DNM1
DNM2
DOK1
DOK2
DOK4
DPYD
EFNA5
EFNB1
EFNB2
EFS
EGFR
EGLN1
EMD
ENO1
ENPP7
EPHA3
EPHA4
EPHB2
EPS8
ERBB2
ERBB3
ERBB4
ERRFI1
ESR1
ESR2
ETS1
ETS2
EVL
FANCC
FARP2
FASLG
FBP2
FBXO5
FGR
FHIT
FLNA
FLT3
FMR1
FOXO1
FRS2
FYB1
FZR1
GAB1
GAB2
GAB3
GALNT12
GFAP
GIT1
GJA1
GJB1
GRB10
GRB2
GRIN2A
GRIN2B
GRK2
GTF2I
GUCY2C
HDAC3
HEMGN
HLA-A
HLA-B
HNF1A
HNRNPK
HRAS
HSP90AA1
IGF1R
IKBKB
IKBKG
IL6R
INPPL1
INSR
ITGB3
ITK
JUP
KCNA5
KCNB1
KCNQ5
KDR
KHDRBS1
KIFAP3
KIT
LRP1
LYN
MAP2
MAP2K1
MAPK15
MAPK3
MAPK8IP3
MAPRE1
MAPT
MATK
MDM2
MED28
MET
MICAL1
MPZL1
MST1R
MT-ND2
MUC1
MYLK
NANS
NCOA6
NEDD4
NFKBIA
NMT1
NOS2
NPHS1
NR1I2
NR1I3
NR3C1
P2RY2
PAK2
PDCD6IP
PDE4D
PDE6G
PDGFRB
PDPK1
PECAM1
PELP1
PGR
PI3
PIK3R1
PIK3R3
PIP5K1C
PKD1
PLCG1
PLD1
PLD2
PLSCR1
PLTP
PPARD
PPARGC1B
PPP2CB
PRKACA
PRKCA
PRKCD
PRKCE
PRKCH
PRKCI
PRKCZ
PRKD1
PROM1
PTK2
PTK2B
PTPA
PTPN1
PTPN11
PTPN18
PTPN2
PTPN21
PTPN6
PTPRA
PTPRC
PTPRE
PTPRT
PXN
RACK1
RAF1
RARA
RASA1
RASGRF1
RET
RGS16
RPL10
RPS6KA3
RPS6KB1
RPS6KB2
RXRA
SH2D3C
SH3BP1
SH3PXD2A
SHB
SHC1
SKAP1
SKAP2
SLC9A2
SMARCB1
SMARCE1
SNCA
SOCS1
SORBS1
SPTAN1
SRCIN1
SRF
SRPK2
STAP2
STAT1
STAT3
STAT5A
STAT5B
STAT6
STUB1
STX17
SYK
SYN1
TAMALIN
TERT
THRA
THRB
TIAM1
TMPO
TNFRSF11A
TNFRSF1A
TNK2
TP53
TRAF1
TRAF3
TRAF6
TRAT1
TRIM50
TRIM7
TRIP10
TRIP6
TRMO
TRPC6
TRPV4
TUB
TXK
TYRO3
USP8
VCL
VDR
VIL1
WAS
WASL
WBP11
WWOX
XPA
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
ZNF189
ZNF687
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173 interacting genes:
AATK
ACTN4
AKT1
AR
ARHGAP1
AXL
BCR
BDKRB2
BEX1
BEX2
BLZF1
BRAP
BTLA
CALR
CAT
CAV1
CBL
CCKBR
CD33
CDH5
CEACAM1
CHUK
CRKL
CSF2RB
CSF3R
CTDSP1
CTLA4
CXCR4
DAB1
DDR1
DMRTC1
EGFR
EPHA1
EPHA2
EPOR
ERBB2
ERBB3
ERBB4
FAM71E1
FBXW7
FCGR1B
FCGR2B
FCRL3
FGFR2
FGFR4
FLT1
FLT3
FLT4
FRS2
FRS3
FYN
GAB1
GAB2
GAB3
GHR
GMNN
GOLGA2
GRB2
GRIN2B
GTF2A2
HIP1R
HNRNPU
HSP90B1
HSPA5
HSPA9
HSPD1
IFNAR1
IFNGR1
IGF1R
IL4R
IL6ST
ILK
INPP5D
INSR
IRS1
IRS2
IRS4
JAK1
JAK2
KDR
KIR2DL5A
KIT
KLRC1
LAIR1
LCK
LEPR
LIFR
LILRB4
LINC01558
LINC02907
LNX1
LRP1
MAP3K4
MAP3K5
MAPK3
MAPT
MET
MPIG6B
MPL
MPZL1
MS4A2
MVK
MVP
NCOR2
NEB
NEDD9
NOX4
NRG3
NSUN5
NSUN5P2
NTRK1
NTRK2
ORMDL3
P2RX7
PAG1
PDGFRA
PDGFRB
PECAM1
PIK3CA
PIK3CG
PIK3R1
PILRA
PILRB
PLCG1
PNCK
POU2AF1
PRKCA
PRKCB
PRKCH
PRLR
PTK2
PTK2B
PTK7
PTPN6
PXN
RANGRF
RCOR3
RET
ROR2
ROS1
RPIA
SELE
SERF2
SERPINF1
SHC1
SIGLEC11
SIGLEC12
SIGLEC7
SIRPA
SIT1
SLAMF1
SLAMF6
SLC38A1
SLN
SOCS3
SOS1
SPRY2
SRC
SRSF10
STAT1
STAT3
STAT5A
STAT5B
SYNCRIP
TEK
TIE1
TLK1
TNFRSF1A
TREML1
TRIM32
TRMT2B
TSC2
TXNIP
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Entrez ID |
6714 |
5781 |
HPRD ID |
01819 |
01470 |
Ensembl ID |
ENSG00000197122
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ENSG00000179295
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Uniprot IDs |
P12931
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Q06124
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PDB IDs |
1A07
1A08
1A09
1A1A
1A1B
1A1C
1A1E
1FMK
1HCS
1HCT
1KSW
1O41
1O42
1O43
1O44
1O45
1O46
1O47
1O48
1O49
1O4A
1O4B
1O4C
1O4D
1O4E
1O4F
1O4G
1O4H
1O4I
1O4J
1O4K
1O4L
1O4M
1O4N
1O4O
1O4P
1O4Q
1O4R
1SHD
1Y57
1YI6
1YOJ
1YOL
1YOM
2BDF
2BDJ
2H8H
2SRC
3VRO
3ZMP
3ZMQ
4F59
4F5A
4F5B
4HXJ
4K11
4MXO
4MXX
4MXY
4MXZ
6ATE
6C4S
6E6E
6EHJ
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2SHP
3B7O
3MOW
3O5X
3TKZ
3TL0
3ZM0
3ZM1
3ZM2
3ZM3
4DGP
4DGX
4GWF
4H1O
4H34
4JE4
4JEG
4JMG
4NWF
4NWG
4OHD
4OHE
4OHH
4OHI
4OHL
4PVG
4QSY
4RDD
5BK8
5DF6
5EHP
5EHR
5I6V
5IBM
5IBS
5X7B
5X94
5XZR
6ATD
6BMR
6BMU
6BMV
6BMW
6BMX
6BMY
6BN5
6CMP
6CMQ
6CMR
6CMS
6CRF
6CRG
6IHZ
6MD7
6MD9
6MDA
6MDB
6MDC
6MDD
6R5G
7JVM
7JVN
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Enriched GO Terms of Interacting Partners? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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