SRC and ITGB3

Number of citations of the paper that reports this interaction (PubMedID 11723131)
22

Data Source:
HPRD (in vivo, in vitro)

		SRC	ITGB3
Description		SRC proto-oncogene, non-receptor tyrosine kinase	integrin subunit beta 3
Image
GO Annotations	Cellular Component	Podosome Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Lysosome Late Endosome Cytosol Actin Filament Plasma Membrane Caveola Focal Adhesion Postsynaptic Density Cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Neuron Projection Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component	Nucleus Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex Cell Surface Platelet Alpha Granule Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Protein-containing Complex Integrin Alphav-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Melanosome Receptor Complex Synapse Postsynaptic Membrane Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Glutamatergic Synapse
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Kinase C Binding Signaling Receptor Binding Insulin Receptor Binding Integrin Binding Protein Binding ATP Binding Protein C-terminus Binding Phospholipase Activator Activity Enzyme Binding Kinase Binding Heme Binding Estrogen Receptor Binding Ubiquitin Protein Ligase Binding SH2 Domain Binding Phospholipase Binding Transmembrane Transporter Binding Cadherin Binding Ephrin Receptor Binding ATPase Binding Phosphoprotein Binding BMP Receptor Binding Growth Factor Receptor Binding Connexin Binding Scaffold Protein Binding	Virus Receptor Activity Fibronectin Binding Protease Binding Protein Disulfide Isomerase Activity Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Coreceptor Activity Fibroblast Growth Factor Binding Enzyme Binding C-X3-C Chemokine Binding Insulin-like Growth Factor I Binding Neuregulin Binding Identical Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding Fibrinogen Binding
	Biological Process	Primary Ovarian Follicle Growth Positive Regulation Of Cytokine Production Stimulatory C-type Lectin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Cycle Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Population Proliferation Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Virus Response To Acidic PH Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Protein Processing Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Cell-cell Adhesion Cell Differentiation Platelet Activation Forebrain Development T Cell Costimulation Negative Regulation Of Protein-containing Complex Assembly Protein Destabilization Response To Nutrient Levels Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase B Activity Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Response To Insulin Stimulus Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Integrin Activation Adherens Junction Organization Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Dephosphorylation Intracellular Signal Transduction Entry Of Bacterium Into Host Cell Osteoclast Development Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ERBB2 Signaling Pathway Odontogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Stress Fiber Assembly Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Binding Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Transcytosis Innate Immune Response Regulation Of Bone Resorption Bone Resorption Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Oogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Progesterone Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Transport Response To Mineralocorticoid Response To Electrical Stimulus Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Mitochondrial Depolarization Negative Regulation Of Telomerase Activity Uterus Development Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cell Projection Assembly Intestinal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Peptide Hormone Stimulus Cellular Response To Progesterone Stimulus Cellular Response To Fatty Acid Cellular Response To Hypoxia Cellular Response To Fluid Shear Stress Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Serine/threonine Kinase Activity Angiotensin-activated Signaling Pathway Involved In Heart Process Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Postsynaptic Neurotransmitter Receptor Activity Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Lamellipodium Morphogenesis Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Caveolin-mediated Endocytosis	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Smooth Muscle Cell Migration Cell Migration Platelet Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Activation Of Protein Kinase Activity Negative Regulation Of Lipid Transport Regulation Of Protein Localization Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Tube Development Apolipoprotein A-I-mediated Signaling Pathway Wound Healing Apoptotic Cell Clearance Regulation Of Bone Resorption Viral Entry Into Host Cell Mesodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Lipoprotein Metabolic Process Negative Chemotaxis Regulation Of Serotonin Uptake Angiogenesis Involved In Wound Healing Platelet Aggregation Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Low-density Lipoprotein Receptor Activity
Pathways		Signaling by ERBB2 Nuclear signaling by ERBB4 Downregulation of ERBB4 signaling PIP3 activates AKT signaling GAB1 signalosome Downstream signal transduction Constitutive Signaling by Aberrant PI3K in Cancer Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Regulation of commissural axon pathfinding by SLIT and ROBO RAF activation MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PTK2 signaling InlA-mediated entry of Listeria monocytogenes into host cells Regulation of RUNX1 Expression and Activity RUNX2 regulates osteoblast differentiation Regulation of RUNX3 expression and activity Extra-nuclear estrogen signaling RHOU GTPase cycle Activated NTRK2 signals through FYN Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Platelet degranulation Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Syndecan interactions Syndecan interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway Signal transduction by L1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Dasatinib RU84687 RU79256 N6-Benzyl Adenosine-5'-Diphosphate RU85493 RU78262 Phosphonotyrosine Malonic acid RU83876 RU90395 RU79072 RU78783 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine PASBN 2-[4-[(Z)-2-Acetamido-3-oxo-3-[[(3S)-2-oxo-1-[(4-phenylphenyl)methyl]azepan-3-yl]amino]prop-1-enyl]-2-formylphenyl]acetic acid PAS219 DPI59 RU82197 Phenylphosphate RU78300 RU79073 RU82209 ISO24 RU85053 RU78299 Oxalic Acid RU78191 Citric acid Paratoulene phosphate 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE Purvalanol A XL228 Tirbanibulin Bosutinib 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL PD-168393 [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile PP-121 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide Ponatinib Nintedanib Fostamatinib	Abciximab Eptifibatide Antithymocyte immunoglobulin (rabbit) Levothyroxine Tirofiban Resveratrol Lefradafiban LM-609 Fradafiban Ferric maltol
Diseases
GWAS		Retinopathy in non-diabetics ( 23393555) Rheumatoid arthritis ( 30891314) Squamous cell carcinoma ( 26908436)	Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 33713608) High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 34021172) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		310 interacting genes: ABL1 ACTN1 ADAM12 ADAM15 ADRB2 ADRB3 AFAP1 AFAP1L2 AGAP1 AKT1 ALDOB ANKRD11 ANXA1 ANXA2 ANXA7 AR ARHGAP1 ARHGAP17 ARHGAP32 ARHGAP35 ARR3 ASAP1 ATG9A ATP2B4 AXL BAAT BARD1 BCAR1 BCCIP BCR BMX CA3 CASP8 CAV1 CAV2 CBL CBLC CCDC180 CCNA1 CD2AP CD33 CD36 CD44 CD46 CD59 CDC25A CDC37 CDCP1 CDH5 CDK1 CDK5 CDKN1B CEACAM1 CEACAM3 CFL1 CHUK CLTC CNTNAP1 COASY CORO7 CRMP1 CSK CTNNB1 CTNND1 CTSV CTTN CUL4B DAB1 DAB2 DAG1 DAPP1 DDR2 DGKA DGKZ DLG4 DNM1 DNM2 DOK1 DOK2 DOK4 DPYD EFNA5 EFNB1 EFNB2 EFS EGFR EGLN1 EMD ENO1 ENPP7 EPHA3 EPHA4 EPHB2 EPS8 ERBB2 ERBB3 ERBB4 ERRFI1 ESR1 ESR2 ETS1 ETS2 EVL FANCC FARP2 FASLG FBP2 FBXO5 FGR FHIT FLNA FLT3 FMR1 FOXO1 FRS2 FYB1 FZR1 GAB1 GAB2 GAB3 GALNT12 GFAP GIT1 GJA1 GJB1 GRB10 GRB2 GRIN2A GRIN2B GRK2 GTF2I GUCY2C HDAC3 HEMGN HLA-A HLA-B HNF1A HNRNPK HRAS HSP90AA1 IGF1R IKBKB IKBKG IL6R INPPL1 INSR ITGB3 ITK JUP KCNA5 KCNB1 KCNQ5 KDR KHDRBS1 KIFAP3 KIT LRP1 LYN MAP2 MAP2K1 MAPK15 MAPK3 MAPK8IP3 MAPRE1 MAPT MATK MDM2 MED28 MET MICAL1 MPZL1 MST1R MT-ND2 MUC1 MYLK NANS NCOA6 NEDD4 NFKBIA NMT1 NOS2 NPHS1 NR1I2 NR1I3 NR3C1 P2RY2 PAK2 PDCD6IP PDE4D PDE6G PDGFRB PDPK1 PECAM1 PELP1 PGR PI3 PIK3R1 PIK3R3 PIP5K1C PKD1 PLCG1 PLD1 PLD2 PLSCR1 PLTP PPARD PPARGC1B PPP2CB PRKACA PRKCA PRKCD PRKCE PRKCH PRKCI PRKCZ PRKD1 PROM1 PTK2 PTK2B PTPA PTPN1 PTPN11 PTPN18 PTPN2 PTPN21 PTPN6 PTPRA PTPRC PTPRE PTPRT PXN RACK1 RAF1 RARA RASA1 RASGRF1 RET RGS16 RPL10 RPS6KA3 RPS6KB1 RPS6KB2 RXRA SH2D3C SH3BP1 SH3PXD2A SHB SHC1 SKAP1 SKAP2 SLC9A2 SMARCB1 SMARCE1 SNCA SOCS1 SORBS1 SPTAN1 SRCIN1 SRF SRPK2 STAP2 STAT1 STAT3 STAT5A STAT5B STAT6 STUB1 STX17 SYK SYN1 TAMALIN TERT THRA THRB TIAM1 TMPO TNFRSF11A TNFRSF1A TNK2 TP53 TRAF1 TRAF3 TRAF6 TRAT1 TRIM50 TRIM7 TRIP10 TRIP6 TRMO TRPC6 TRPV4 TUB TXK TYRO3 USP8 VCL VDR VIL1 WAS WASL WBP11 WWOX XPA YTHDC1 YWHAB YWHAE YWHAG YWHAH ZNF189 ZNF687	49 interacting genes: AKT1 ANGPTL3 APP CAPN1 CD36 CDK1 COL1A2 DAB1 DAB2 DOK1 EPS8 FBLN2 FGA FGFR1 FGG FLNA FLNB FN1 GRIA2 HRAS ILK ITGA2B ITGA5 ITGAV ITGB3BP KDR MAPK3 NID1 NUMB P2RY2 P4HB PDGFRA PDGFRB PDK1 PDPK1 PECAM1 PLA2G2A PLA2G4A PTK2 PTK2B PXN SHC1 SRC TGM2 THBS1 THY1 TLN1 TNS2 VTN
Entrez ID		6714	3690
HPRD ID		01819	01428
Ensembl ID		ENSG00000197122	ENSG00000259207
Uniprot IDs		P12931	P05106
PDB IDs		1A07 1A08 1A09 1A1A 1A1B 1A1C 1A1E 1FMK 1HCS 1HCT 1KSW 1O41 1O42 1O43 1O44 1O45 1O46 1O47 1O48 1O49 1O4A 1O4B 1O4C 1O4D 1O4E 1O4F 1O4G 1O4H 1O4I 1O4J 1O4K 1O4L 1O4M 1O4N 1O4O 1O4P 1O4Q 1O4R 1SHD 1Y57 1YI6 1YOJ 1YOL 1YOM 2BDF 2BDJ 2H8H 2SRC 3VRO 3ZMP 3ZMQ 4F59 4F5A 4F5B 4HXJ 4K11 4MXO 4MXX 4MXY 4MXZ 6ATE 6C4S 6E6E 6EHJ	1JV2 1KUP 1KUZ 1L5G 1M1X 1M8O 1MIZ 1MK7 1MK9 1RN0 1S4X 1TYE 1U8C 2INI 2K9J 2KNC 2KV9 2L1C 2L91 2LJD 2LJE 2LJF 2MTP 2N9Y 2Q6W 2RMZ 2RN0 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3IJE 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4CAK 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4Z7N 4Z7O 4Z7Q 5HDB 6AVQ 6AVR 6AVU 6BXB 6BXF 6BXJ 6CKB 6MK0 6MSL 6MSU 6NAJ 6V4P
Enriched GO Terms of Interacting Partners?
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