BPI and PRSS2

Number of citations of the paper that reports this interaction (PubMedID 11420435)
5

Data Source:
HPRD (in vitro)

		BPI	PRSS2
Description		bactericidal permeability increasing protein	serine protease 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Extracellular Matrix Azurophil Granule Lumen
	Molecular Function	Lipopolysaccharide Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity
	Biological Process	Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Macrophage Activation Innate Immune Response Defense Response To Gram-negative Bacterium	Proteolysis Digestion Antimicrobial Humoral Response Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Collagen Catabolic Process Positive Regulation Of Cell Adhesion
Pathways		Toll Like Receptor 4 (TLR4) Cascade Neutrophil degranulation Antimicrobial peptides	Collagen degradation Alpha-defensins Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides
Drugs		Di-Stearoyl-3-Sn-Phosphatidylcholine	Monoisopropylphosphorylserine O-Benzylsulfonyl-Serine Benzylamine Benzamidine Phosphorylisopropane Phenethylamine 3-Phenylpropylamine
Diseases
GWAS		Basophil count ( 32888494) Blood protein levels ( 29875488) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) White blood cell count ( 32888494)	Blood protein levels ( 29875488) Pancreatitis ( 23143602)
Interacting Genes		2 interacting genes: ATP6V0B PRSS2	9 interacting genes: APP BPI CSN1S1 DMBT1 GLP1R MKKS MMP9 SERPINA1 SLPI
Entrez ID		671	5645
HPRD ID		00174	03335
Ensembl ID		ENSG00000101425	ENSG00000275896
Uniprot IDs		P17213	A6XMV9 P07478 Q5NV56 Q6PK75
PDB IDs		1BP1 1EWF
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?