PRSS2 and SLPI

Number of citations of the paper that reports this interaction (PubMedID 8573092)
3

Data Source:
HPRD (in vitro)

		PRSS2	SLPI
Description		serine protease 2	secretory leukocyte peptidase inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Azurophil Granule Lumen	Extracellular Region Extracellular Space Golgi Apparatus Specific Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity	DNA Binding MRNA Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding
	Biological Process	Proteolysis Digestion Antimicrobial Humoral Response Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Collagen Catabolic Process Positive Regulation Of Cell Adhesion	Immune Response Negative Regulation Of Endopeptidase Activity Antibacterial Humoral Response Negative Regulation Of Protein Binding Response To Lipopolysaccharide Modulation Of Process Of Other Organism Negative Regulation Of Viral Genome Replication Innate Immune Response
Pathways		Collagen degradation Alpha-defensins Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides	Neutrophil degranulation
Drugs		Monoisopropylphosphorylserine O-Benzylsulfonyl-Serine Benzylamine Benzamidine Phosphorylisopropane Phenethylamine 3-Phenylpropylamine
Diseases
GWAS		Blood protein levels ( 29875488) Pancreatitis ( 23143602)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576 28240269) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Malaria ( 31844061)
Interacting Genes		9 interacting genes: APP BPI CSN1S1 DMBT1 GLP1R MKKS MMP9 SERPINA1 SLPI	25 interacting genes: CALN1 CIB3 CTSB CTSL CTSS EFEMP1 ELANE FAM9B GRN HOXA1 KLK3 LAT MAPK8IP2 MICOS10-NBL1 MKRN3 NBL1 NTAQ1 PIH1D2 PLSCR1 PRSS2 SGTA SGTB SMIM14 UBQLN1 UBQLN2
Entrez ID		5645	6590
HPRD ID		03335	00121
Ensembl ID		ENSG00000275896	ENSG00000124107
Uniprot IDs		A6XMV9 P07478 Q5NV56 Q6PK75	P03973
PDB IDs			2Z7F 4DOQ
Enriched GO Terms of Interacting Partners?
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