SPN and SIGLEC1

Number of citations of the paper that reports this interaction (PubMedID 11238599)
43

Data Source:
HPRD (in vivo)

		SPN	SIGLEC1
Description		sialophorin	sialic acid binding Ig like lectin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Uropod Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane PML Body Extracellular Exosome	Extracellular Region Early Endosome Late Endosome Plasma Membrane Integral Component Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding	Carbohydrate Binding Virion Binding
	Biological Process	T-helper 1 Cell Lineage Commitment Chemotaxis Immune Response Cellular Defense Response Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Regulation Of Immune Response Leukocyte Tethering Or Rolling Regulation Of T Cell Migration Positive Regulation Of T Cell Migration	Inflammatory Response Cell-matrix Adhesion Clathrin-dependent Endocytosis Of Virus By Host Cell Cell-cell Adhesion
Pathways		Cell surface interactions at the vascular wall Basigin interactions	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs			Beta-D-Glucose N-acetyl-alpha-neuraminic acid
Diseases
GWAS			Blood protein levels ( 29875488) IgM levels ( 28628107) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Night sleep phenotypes ( 27126917) Reticulocyte fraction of red cells ( 32888494) Visceral fat ( 30942860)
Interacting Genes		18 interacting genes: ARL13B CLCA4 CTNNB1 CTSA CXCL16 CYBC1 DAXX ERGIC3 EZR FYN ICAM1 LGALS1 LMNA MSN PLP2 SGTA SIGLEC1 UBQLN2	3 interacting genes: MUC1 SPN TNR
Entrez ID		6693	6614
HPRD ID		06770	02854
Ensembl ID		ENSG00000197471	ENSG00000088827
Uniprot IDs		A0A024R629 P16150	Q9BZZ2
PDB IDs
Enriched GO Terms of Interacting Partners?
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