SIGLEC1 and SPN

Number of citations of the paper that reports this interaction (PubMedID 11238599)
43

Data Source:
HPRD (in vivo)

		SIGLEC1	SPN
Description		sialic acid binding Ig like lectin 1	sialophorin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Early Endosome Late Endosome Plasma Membrane Integral Component Of Membrane	Uropod Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane PML Body Extracellular Exosome
	Molecular Function	Carbohydrate Binding Virion Binding	Transmembrane Signaling Receptor Activity Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding
	Biological Process	Inflammatory Response Cell-matrix Adhesion Clathrin-dependent Endocytosis Of Virus By Host Cell Cell-cell Adhesion	T-helper 1 Cell Lineage Commitment Chemotaxis Immune Response Cellular Defense Response Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Regulation Of Immune Response Leukocyte Tethering Or Rolling Regulation Of T Cell Migration Positive Regulation Of T Cell Migration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Cell surface interactions at the vascular wall Basigin interactions
Drugs		Beta-D-Glucose N-acetyl-alpha-neuraminic acid
Diseases
GWAS		Blood protein levels ( 29875488) IgM levels ( 28628107) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Night sleep phenotypes ( 27126917) Reticulocyte fraction of red cells ( 32888494) Visceral fat ( 30942860)
Interacting Genes		3 interacting genes: MUC1 SPN TNR	18 interacting genes: ARL13B CLCA4 CTNNB1 CTSA CXCL16 CYBC1 DAXX ERGIC3 EZR FYN ICAM1 LGALS1 LMNA MSN PLP2 SGTA SIGLEC1 UBQLN2
Entrez ID		6614	6693
HPRD ID		02854	06770
Ensembl ID		ENSG00000088827	ENSG00000197471
Uniprot IDs		Q9BZZ2	A0A024R629 P16150
PDB IDs
Enriched GO Terms of Interacting Partners?
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