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SP1 and IL1B
Number of citations of the paper that reports this interaction (PubMedID
22455954
)
9
Data Source:
BioGRID
(two hybrid)
SP1
IL1B
Description
Sp1 transcription factor
interleukin 1 beta
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Cytoplasm
Transcription Repressor Complex
Protein-DNA Complex
Extracellular Region
Extracellular Space
Lysosome
Cytosol
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Histone Acetyltransferase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
BHLH Transcription Factor Binding
Sequence-specific DNA Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
HMG Box Domain Binding
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Cytokine Activity
Interleukin-1 Receptor Binding
Integrin Binding
Protein Binding
Protein Domain Specific Binding
Biological Process
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Gene Expression
Cellular Response To Insulin Stimulus
Response To Hydroperoxide
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation By Host Of Viral Transcription
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Positive Regulation Of Amyloid-beta Formation
Positive Regulation Of Hydrogen Sulfide Biosynthetic Process
Positive Regulation Of Vascular Endothelial Cell Proliferation
MAPK Cascade
Fever Generation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of T Cell Mediated Immunity
Apoptotic Process
Inflammatory Response
Immune Response
Signal Transduction
Cell-cell Signaling
Embryo Implantation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Vascular Endothelial Growth Factor Production
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Glucose Transmembrane Transport
Smooth Muscle Adaptation
Cytokine-mediated Signaling Pathway
Hyaluronan Biosynthetic Process
Positive Regulation Of Cell Migration
Sequestering Of Triglyceride
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Fever Generation
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Prostaglandin Secretion
Response To Lipopolysaccharide
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Histone Phosphorylation
Positive Regulation Of Heterotypic Cell-cell Adhesion
Positive Regulation Of Histone Acetylation
Positive Regulation Of Myosin Light Chain Kinase Activity
Positive Regulation Of T Cell Proliferation
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAP Kinase Activity
Negative Regulation Of MAP Kinase Activity
Protein Kinase B Signaling
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Angiogenesis
Negative Regulation Of Lipid Metabolic Process
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Complement Activation
Positive Regulation Of JNK Cascade
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Protein Export From Nucleus
Positive Regulation Of Inflammatory Response
Positive Regulation Of Phagocytosis
Regulation Of Neurogenesis
Negative Regulation Of Neurogenesis
Regulation Of Insulin Secretion
Negative Regulation Of Synaptic Transmission
Negative Regulation Of Lipid Catabolic Process
Positive Regulation Of Lipid Catabolic Process
Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Cell Division
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Cell Adhesion Molecule Production
Positive Regulation Of Calcidiol 1-monooxygenase Activity
Negative Regulation Of Adiponectin Secretion
Regulation Of ERK1 And ERK2 Cascade
Monocyte Aggregation
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Organic Substance
Cellular Response To Organic Cyclic Compound
Cellular Response To Xenobiotic Stimulus
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Positive Regulation Of Neuroinflammatory Response
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Gap Junction Assembly
Positive Regulation Of T-helper 1 Cell Cytokine Production
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
PPARA activates gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Activation of gene expression by SREBF (SREBP)
Oncogene Induced Senescence
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
Estrogen-dependent gene expression
Interleukin-1 processing
Pyroptosis
CLEC7A/inflammasome pathway
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-1 signaling
Purinergic signaling in leishmaniasis infection
Drugs
Donepezil
Minocycline
VP025
Gallium nitrate
Talmapimod
Etiprednol dicloacetate
VX-702
VX-765
Andrographolide
Canakinumab
Rilonacept
Foreskin keratinocyte (neonatal)
Binimetinib
Gevokizumab
Dilmapimod
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
High light scatter reticulocyte count (
32888494
)
Hypospadias (moderate to severe) (
31856834
)
Mean corpuscular hemoglobin (
29403010
)
Mean corpuscular volume (
29403010
32888494
)
Mean spheric corpuscular volume (
32888494
)
Neutrophil percentage of white cells (
27863252
)
Parkinsonism in frontotemporal lobe dementia (
29724592
)
Percentage gas trapping (
26030696
)
Progressive supranuclear palsy (
30089514
)
Red blood cell count (
32888494
27863252
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Birth weight (
31043758
)
Dysmenorrheic pain severity (
29855537
)
Gestational age at birth (child effect) (
31477735
)
Post-term birth (
31477735
)
Interacting Genes
152 interacting genes:
AATF
AHR
AKT1
AR
ARHGAP21
ARNT
ATF7IP
ATF7IP2
BCL11B
BCL6
BCOR
BRCA1
CASP3
CASP6
CASP7
CBX5
CCNA1
CCNA2
CCND1
CD2
CDK1
CDK2
CEBPB
CSNK2A1
CTCFL
CTNNB1
DDX5
DROSHA
E2F1
E2F2
E2F3
EGR1
ELF1
ENDOU
EP300
ESR1
ESR2
ESRRA
ESRRB
ESRRG
ETS1
GABPA
GATA1
GATA3
GATA4
GRIN1
HBZ
HCFC1
HDAC1
HDAC2
HIF1A
HINT1
HLTF
HMGA1
HNF4A
HNRNPA1
HOXC11
HSPA8
HTT
IL1B
JUN
KIF1A
KLF10
KLF4
KLF6
LDB1
LMO2
MAPK1
MAPK3
MAPK8
MBD1
MEF2C
MEF2D
MIER1
MIS18BP1
MSX1
MTREX
MYC
MYCN
MYOD1
MYOG
NAP1L1
NCOR1
NCOR2
NEDD4L
NEPRO
NFKB1
NFKB2
NFYA
NFYB
NFYC
NKX3-1
NOS3
NPM1
NR2F1
NR5A1
NUP62
OGT
PARP1
PER3
PML
POGZ
POU2F1
PPIG
PPP1R13L
PRKCZ
PRKDC
PSIP1
PSMC5
PURA
RAPGEF3
RARA
RB1
RBBP4
RBL1
REG1A
REL
RELA
RNF4
RORA
RXRA
SENP6
SF3A1
SHC1
SMAD2
SMAD3
SMAD4
SMARCC1
SMARCC2
SOX10
SOX8
SP3
SP4
SREBF1
SREBF2
SRF
SUB1
SUMO2
TAF4
TAL1
TBP
TLX3
TP53
TP73
TPI1
USP39
VEGFA
VHL
YY1
ZBTB16
ZBTB2
ZBTB7A
17 interacting genes:
A2M
ADRB2
APP
CASP1
CASP4
CMA1
EGR1
FURIN
FYN
IL1R1
IL1R2
IL1RAP
LYN
MMP2
NEDD4
PRTN3
SP1
Entrez ID
6667
3553
HPRD ID
01796
00985
Ensembl ID
ENSG00000185591
ENSG00000125538
Uniprot IDs
P08047
P01584
PDB IDs
1SP1
1SP2
1VA1
1VA2
1VA3
6PV0
6PV1
6PV2
6PV3
6UCO
6UCP
1HIB
1I1B
1IOB
1ITB
1L2H
1S0L
1T4Q
1TOO
1TP0
1TWE
1TWM
21BI
2I1B
2KH2
2NVH
31BI
3LTQ
3O4O
3POK
41BI
4DEP
4G6J
4G6M
4GAF
4GAI
4I1B
5BVP
5I1B
5MVZ
5R7W
5R85
5R86
5R87
5R88
5R89
5R8A
5R8B
5R8C
5R8D
5R8E
5R8F
5R8G
5R8H
5R8I
5R8J
5R8K
5R8L
5R8M
5R8N
5R8O
5R8P
5R8Q
6I1B
6Y8I
6Y8M
7CHY
7CHZ
7I1B
9ILB
Enriched GO Terms of Interacting Partners
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