SOD2 and HDHD2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		SOD2	HDHD2
Description		superoxide dismutase 2	haloacid dehalogenase like hydrolase domain containing 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid Extracellular Exosome	Extracellular Exosome
	Molecular Function	DNA Binding Superoxide Dismutase Activity Protein Binding Oxygen Binding Enzyme Binding Manganese Ion Binding Identical Protein Binding	Protein Binding Phosphatase Activity Enzyme Binding Metal Ion Binding
	Biological Process	Response To Superoxide Age-dependent Response To Reactive Oxygen Species Response To Hypoxia Release Of Cytochrome C From Mitochondria Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Superoxide Metabolic Process Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Response To Radiation Response To Cold Response To Xenobiotic Stimulus Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Response To Activity Removal Of Superoxide Radicals Positive Regulation Of Cell Migration Oxygen Homeostasis Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Silicon Dioxide Response To Isolation Stress Response To Immobilization Stress Response To Hydrogen Peroxide Negative Regulation Of Neuron Apoptotic Process Response To Cadmium Ion Hydrogen Peroxide Biosynthetic Process Protein Homotetramerization Response To Electrical Stimulus Response To Magnetism Cellular Response To Ethanol Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Membrane Hyperpolarization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	Biological_process Dephosphorylation
Pathways		Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		Benzylsulfonic acid 3-Fluoro-L-tyrosine
Diseases
GWAS		Age-related macular degeneration (geographic atrophy) ( 22705344) Erosive tooth wear (severe vs non-severe) ( 29898447) Lipoprotein (a) levels ( 26377243) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Polycystic ovary syndrome ( 32289280) Pulse pressure ( 27841878)	Blood protein levels ( 30072576 29875488) Fruit consumption ( 32066663)
Interacting Genes		10 interacting genes: APP CEP70 CYP4F12 DRC3 GET4 HDHD2 KIAA1549 NOL12 RAB4A RPS3A	12 interacting genes: ADGRB2 CFD CRMP1 DVL1 EPHB6 LUC7L2 MEOX2 MGST2 PIP5K1C SOD2 TARBP2 TRAPPC11
Entrez ID		6648	84064
HPRD ID		00938	13640
Ensembl ID		ENSG00000112096	ENSG00000167220
Uniprot IDs		A0A384NL29 G5E9P6 P04179 Q96AM7 Q9UG59	Q9H0R4 V9HW73
PDB IDs		1AP5 1AP6 1EM1 1JA8 1LUV 1LUW 1MSD 1N0J 1N0N 1PL4 1PM9 1QNM 1SZX 1VAR 1XDC 1XIL 1ZSP 1ZTE 1ZUQ 2ADP 2ADQ 2GDS 2P4K 2QKA 2QKC 3C3S 3C3T 5GXO 5T30 5VF9	3HLT
Enriched GO Terms of Interacting Partners?
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