SOD2 and NOL12

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SOD2	NOL12
Description		superoxide dismutase 2	nucleolar protein 12
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid Extracellular Exosome	Nucleolus
	Molecular Function	DNA Binding Superoxide Dismutase Activity Protein Binding Oxygen Binding Enzyme Binding Manganese Ion Binding Identical Protein Binding	RNA Binding Protein Binding RRNA Binding Identical Protein Binding
	Biological Process	Response To Superoxide Age-dependent Response To Reactive Oxygen Species Response To Hypoxia Release Of Cytochrome C From Mitochondria Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Superoxide Metabolic Process Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Response To Radiation Response To Cold Response To Xenobiotic Stimulus Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Response To Activity Removal Of Superoxide Radicals Positive Regulation Of Cell Migration Oxygen Homeostasis Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Silicon Dioxide Response To Isolation Stress Response To Immobilization Stress Response To Hydrogen Peroxide Negative Regulation Of Neuron Apoptotic Process Response To Cadmium Ion Hydrogen Peroxide Biosynthetic Process Protein Homotetramerization Response To Electrical Stimulus Response To Magnetism Cellular Response To Ethanol Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Membrane Hyperpolarization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Benzylsulfonic acid 3-Fluoro-L-tyrosine
Diseases
GWAS		Age-related macular degeneration (geographic atrophy) ( 22705344) Erosive tooth wear (severe vs non-severe) ( 29898447) Lipoprotein (a) levels ( 26377243) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Polycystic ovary syndrome ( 32289280) Pulse pressure ( 27841878)	Basophil count ( 32888494) Brain morphology (MOSTest) ( 32665545) Pulse pressure ( 30224653)
Interacting Genes		10 interacting genes: APP CEP70 CYP4F12 DRC3 GET4 HDHD2 KIAA1549 NOL12 RAB4A RPS3A	19 interacting genes: APP BEND7 CDCA7L CDK4 CEP70 DVL2 DVL3 KIAA1191 KRTAP10-6 KRTAP10-7 MCC SAP18 SF3B3 SLC25A38 SOD2 SPANXN2 SSX2IP TERF1 TSPYL2
Entrez ID		6648	79159
HPRD ID		00938	17537
Ensembl ID		ENSG00000112096	ENSG00000273899
Uniprot IDs		A0A384NL29 G5E9P6 P04179 Q96AM7 Q9UG59	A0A024R1M6 Q9UGY1
PDB IDs		1AP5 1AP6 1EM1 1JA8 1LUV 1LUW 1MSD 1N0J 1N0N 1PL4 1PM9 1QNM 1SZX 1VAR 1XDC 1XIL 1ZSP 1ZTE 1ZUQ 2ADP 2ADQ 2GDS 2P4K 2QKA 2QKC 3C3S 3C3T 5GXO 5T30 5VF9
Enriched GO Terms of Interacting Partners?
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