GPBP1 and PRPF18

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GPBP1	PRPF18
Description		GC-rich promoter binding protein 1	pre-mRNA processing factor 18
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle	Nucleus Spliceosomal Complex U5 SnRNP Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Post-spliceosomal Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding	Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Generation Of Catalytic Spliceosome For Second Transesterification Step MRNA Processing RNA Splicing Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription
Pathways
Drugs
Diseases
GWAS		Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 33768542) Diastolic blood pressure ( 27841878) Nontraumatic osteonecrosis of the femoral head ( 32701715) Normal facial asymmetry (angle of deformation score) ( 30631343) Zinc levels ( 26025379)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) Craniofacial microsomia ( 26853712) Lupus nephritis in systemic lupus erythematosus ( 24925725) Post bronchodilator FEV1/FVC ratio ( 26634245) Skin pigmentation ( 28300201)
Interacting Genes		15 interacting genes: CCDC57 DNAL4 EP300 FAM161A FNDC11 HSF2BP MCRS1 MORF4L2 NXF1 PLEKHF2 PRPF18 PSMB1 QARS1 RACK1 TSC22D2	81 interacting genes: AGTRAP AMOTL2 AP2M1 ASCC2 BEGAIN BICD2 BLZF1 CADPS CALCOCO2 CARD10 CARD9 CBY2 CCDC102B CCDC136 CCDC150 CCDC57 CCNC CDR2 CEP70 CSRNP1 DVL3 EFHC2 EVI5L FERMT3 FSD2 GAS8 GCC1 GOLGA2 GOLGA6L9 GPBP1 GRIPAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKBKG IKZF1 KANK2 KCTD7 KIFC3 KRT31 KRT34 KRT35 KRT39 KRT40 LDOC1 LZTS1 LZTS2 MCC MDFI MEOX2 MTUS2 NACC1 NECAB2 NINL NUTM1 NUTM2F OSBPL3 PDE9A PFDN5 PIBF1 PICK1 PLEKHG4 PNMA1 PPIH PRKAR1B RHOU RINT1 SCHIP1 SPRED1 STX11 TRAF2 TRIM23 TRIM27 TRIM54 TSNAX TSNAXIP1 UBXN11 ZNF526 ZNF639 ZRANB1
Entrez ID		65056	8559
HPRD ID		16333	05407
Ensembl ID		ENSG00000062194	ENSG00000165630
Uniprot IDs		D4PHA4 Q86WP2	Q99633
PDB IDs			2DK4
Enriched GO Terms of Interacting Partners?
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