PRPF18 and AMOTL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PRPF18	AMOTL2
Description		pre-mRNA processing factor 18	angiomotin like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex U5 SnRNP Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Post-spliceosomal Complex	Cytosol Plasma Membrane Bicellular Tight Junction Cytoplasmic Vesicle Recycling Endosome
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Generation Of Catalytic Spliceosome For Second Transesterification Step MRNA Processing RNA Splicing Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription	Angiogenesis Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Wnt Signaling Pathway Actin Cytoskeleton Organization Regulation Of Cell Migration Hippo Signaling
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) Craniofacial microsomia ( 26853712) Lupus nephritis in systemic lupus erythematosus ( 24925725) Post bronchodilator FEV1/FVC ratio ( 26634245) Skin pigmentation ( 28300201)	Cadmium levels ( 26025379) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte fraction of red cells ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
Interacting Genes		81 interacting genes: AGTRAP AMOTL2 AP2M1 ASCC2 BEGAIN BICD2 BLZF1 CADPS CALCOCO2 CARD10 CARD9 CBY2 CCDC102B CCDC136 CCDC150 CCDC57 CCNC CDR2 CEP70 CSRNP1 DVL3 EFHC2 EVI5L FERMT3 FSD2 GAS8 GCC1 GOLGA2 GOLGA6L9 GPBP1 GRIPAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKBKG IKZF1 KANK2 KCTD7 KIFC3 KRT31 KRT34 KRT35 KRT39 KRT40 LDOC1 LZTS1 LZTS2 MCC MDFI MEOX2 MTUS2 NACC1 NECAB2 NINL NUTM1 NUTM2F OSBPL3 PDE9A PFDN5 PIBF1 PICK1 PLEKHG4 PNMA1 PPIH PRKAR1B RHOU RINT1 SCHIP1 SPRED1 STX11 TRAF2 TRIM23 TRIM27 TRIM54 TSNAX TSNAXIP1 UBXN11 ZNF526 ZNF639 ZRANB1	92 interacting genes: AMOT BFSP2 BLZF1 BRMS1L BYSL CARD9 CCDC185 CCDC196 CCDC57 CCHCR1 CDC37 CDR2 CHCHD3 CINP CYTH4 DAXX DDIT3 DTNB DYNLL1 DZIP1L EIF4E2 EPHB1 FAM184A FAM90A1 FBXO7 FCRL5 FXR2 GCC1 GNG11 GNG5 GOLGA2 GSTM5 KIF9 KRT1 KRT13 KRT15 KRT19 KRT20 KRT31 KRT38 KRTAP10-5 KRTAP4-2 L3MBTL2 LMNB2 LMO3 LMO4 MAD1L1 MAGEA4 MAGOHB MFAP1 MORF4L2 MPP1 MTMR6 MTNR1A MYO5B NDC80 NF2 NFIL3 NME7 NTAQ1 PIBF1 PPP2CA PPP2R1A PRKAA2 PRPF18 PSMC3 RAD51D RALBP1 RASAL3 RASSF5 RNF20 RNF40 RNF8 SAAL1 SH3RF2 SMARCE1 SOGA1 SP100 SPAG5 SPOP SPP1 TCEA2 THRA TMCC2 TNKS2 TRAF2 TRIM27 TSGA10IP YES1 ZBED1 ZBTB16 ZGPAT
Entrez ID		8559	51421
HPRD ID		05407	16485
Ensembl ID		ENSG00000165630	ENSG00000114019
Uniprot IDs		Q99633	Q9Y2J4
PDB IDs		2DK4
Enriched GO Terms of Interacting Partners?
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