KLC2 and S100A8

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		KLC2	S100A8
Description		kinesin light chain 2	S100 calcium binding protein A8
Image
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Lysosomal Membrane Cytosol Kinesin Complex Microtubule Plasma Membrane Membrane Kinesin I Complex Protein-containing Complex	Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Secretory Granule Lumen Intermediate Filament Cytoskeleton Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Kinesin Binding Cadherin Binding	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Toll-like Receptor 4 Binding Calcium-dependent Protein Binding Arachidonic Acid Binding RAGE Receptor Binding
	Biological Process	Lysosome Localization	Leukocyte Migration Involved In Inflammatory Response Acute Inflammatory Response Chronic Inflammatory Response Positive Regulation Of Peptide Secretion Autophagy Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Response To Zinc Ion Astrocyte Development Peptidyl-cysteine S-nitrosylation Positive Regulation Of Cell Growth Neutrophil Chemotaxis Sequestering Of Zinc Ion Response To Lipopolysaccharide Autocrine Signaling Wound Healing Defense Response To Bacterium Innate Immune Response Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins
Drugs			Calcium Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Bipolar disorder ( 21926972 31043756) Metabolite levels ( 23823483)	Asthma ( 31619474) Matrix metalloproteinase-8 levels ( 29212897) Monocyte count ( 32888494)
Interacting Genes		18 interacting genes: AIMP2 APP CLSTN1 COIL DDX41 DYNC1I1 KIF2A KLC1 KLC4 LRRK2 MAPK8IP3 PACS1 PIK3R3 PRC1 S100A8 YWHAG YWHAQ YWHAZ	22 interacting genes: APP CDKN1A CEACAM3 CHGB ERG28 GDF9 IGSF21 KLC2 LRIF1 NCF2 PABPC4 PDCD11 PPIA PRMT1 PTEN RAB17 S100A9 TP53 TUBA1A TUBA4A TUBB UNC119
Entrez ID		64837	6279
HPRD ID		13917	00471
Ensembl ID		ENSG00000174996	ENSG00000143546
Uniprot IDs		Q9H0B6	P05109
PDB IDs		3CEQ 3EDT	1MR8 1XK4 4GGF 4XJK 5HLO 5HLV 5W1F 6DS2
Enriched GO Terms of Interacting Partners?
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