S100A8 and RAB17

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		S100A8	RAB17
Description		S100 calcium binding protein A8	RAB17, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Secretory Granule Lumen Intermediate Filament Cytoskeleton Collagen-containing Extracellular Matrix Extracellular Exosome	Endosome Early Endosome Plasma Membrane Endomembrane System Basolateral Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Dendrite Melanosome Neuronal Cell Body Recycling Endosome Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Toll-like Receptor 4 Binding Calcium-dependent Protein Binding Arachidonic Acid Binding RAGE Receptor Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Leukocyte Migration Involved In Inflammatory Response Acute Inflammatory Response Chronic Inflammatory Response Positive Regulation Of Peptide Secretion Autophagy Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Response To Zinc Ion Astrocyte Development Peptidyl-cysteine S-nitrosylation Positive Regulation Of Cell Growth Neutrophil Chemotaxis Sequestering Of Zinc Ion Response To Lipopolysaccharide Autocrine Signaling Wound Healing Defense Response To Bacterium Innate Immune Response Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Intracellular Protein Transport Endocytosis Regulation Of Endocytosis Establishment Of Melanosome Localization Melanosome Transport Endocytic Recycling Transcytosis Filopodium Assembly Regulation Of Dendrite Development Regulation Of Filopodium Assembly Regulation Of Synapse Assembly Cilium Assembly
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins	RAB geranylgeranylation
Drugs		Calcium Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Asthma ( 31619474) Matrix metalloproteinase-8 levels ( 29212897) Monocyte count ( 32888494)	Obesity-related traits ( 23251661)
Interacting Genes		22 interacting genes: APP CDKN1A CEACAM3 CHGB ERG28 GDF9 IGSF21 KLC2 LRIF1 NCF2 PABPC4 PDCD11 PPIA PRMT1 PTEN RAB17 S100A9 TP53 TUBA1A TUBA4A TUBB UNC119	10 interacting genes: ACVR1 BOLA3 C11orf49 FAM9B MAGEA1 NUDT3 RAB7A RABAC1 S100A8 SMURF2
Entrez ID		6279	64284
HPRD ID		00471	11468
Ensembl ID		ENSG00000143546	ENSG00000124839
Uniprot IDs		P05109	A0A024R4A4 Q9H0T7
PDB IDs		1MR8 1XK4 4GGF 4XJK 5HLO 5HLV 5W1F 6DS2
Enriched GO Terms of Interacting Partners?
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