S100A8 and KLC2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		S100A8	KLC2
Description		S100 calcium binding protein A8	kinesin light chain 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Secretory Granule Lumen Intermediate Filament Cytoskeleton Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleoplasm Mitochondrion Lysosomal Membrane Cytosol Kinesin Complex Microtubule Plasma Membrane Membrane Kinesin I Complex Protein-containing Complex
	Molecular Function	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Toll-like Receptor 4 Binding Calcium-dependent Protein Binding Arachidonic Acid Binding RAGE Receptor Binding	Protein Binding Kinesin Binding Cadherin Binding
	Biological Process	Leukocyte Migration Involved In Inflammatory Response Acute Inflammatory Response Chronic Inflammatory Response Positive Regulation Of Peptide Secretion Autophagy Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Response To Zinc Ion Astrocyte Development Peptidyl-cysteine S-nitrosylation Positive Regulation Of Cell Growth Neutrophil Chemotaxis Sequestering Of Zinc Ion Response To Lipopolysaccharide Autocrine Signaling Wound Healing Defense Response To Bacterium Innate Immune Response Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Lysosome Localization
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins	MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs		Calcium Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Asthma ( 31619474) Matrix metalloproteinase-8 levels ( 29212897) Monocyte count ( 32888494)	Bipolar disorder ( 21926972 31043756) Metabolite levels ( 23823483)
Interacting Genes		22 interacting genes: APP CDKN1A CEACAM3 CHGB ERG28 GDF9 IGSF21 KLC2 LRIF1 NCF2 PABPC4 PDCD11 PPIA PRMT1 PTEN RAB17 S100A9 TP53 TUBA1A TUBA4A TUBB UNC119	18 interacting genes: AIMP2 APP CLSTN1 COIL DDX41 DYNC1I1 KIF2A KLC1 KLC4 LRRK2 MAPK8IP3 PACS1 PIK3R3 PRC1 S100A8 YWHAG YWHAQ YWHAZ
Entrez ID		6279	64837
HPRD ID		00471	13917
Ensembl ID		ENSG00000143546	ENSG00000174996
Uniprot IDs		P05109	Q9H0B6
PDB IDs		1MR8 1XK4 4GGF 4XJK 5HLO 5HLV 5W1F 6DS2	3CEQ 3EDT
Enriched GO Terms of Interacting Partners?
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