BMI1 and H2AX

Number of citations of the paper that reports this interaction (PubMedID 21676867)
69

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		BMI1	H2AX
Description		BMI1 proto-oncogene, polycomb ring finger	H2A.X variant histone
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Heterochromatin Nucleus Nucleoplasm Cytosol Nuclear Body PcG Protein Complex PRC1 Complex	Chromosome, Telomeric Region Nucleosome Condensed Nuclear Chromosome Male Germ Cell Nucleus XY Body Nucleus Nucleoplasm Replication Fork Centrosome Nuclear Speck Site Of Double-strand Break Extracellular Exosome Site Of DNA Damage
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Zinc Ion Binding RING-like Zinc Finger Domain Binding Ubiquitin-protein Transferase Activator Activity Promoter-specific Chromatin Binding	DNA Binding Damaged DNA Binding Protein Binding Enzyme Binding Histone Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development DNA Methylation Humoral Immune Response Segment Specification Brain Development Regulation Of Gene Expression Histone Acetylation Rostrocaudal Neural Tube Patterning Hemopoiesis Positive Regulation Of B Cell Proliferation Positive Regulation Of Immature T Cell Proliferation In Thymus Histone H2A-K119 Monoubiquitination Negative Regulation Of Gene Expression, Epigenetic Somatic Stem Cell Division Positive Regulation Of Fibroblast Proliferation Embryonic Skeletal System Morphogenesis Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus Regulation Of Adaxial/abaxial Pattern Formation Negative Regulation Of Apoptotic Signaling Pathway	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Nucleosome Assembly Cellular Response To DNA Damage Stimulus Spermatogenesis Response To Ionizing Radiation Cerebral Cortex Development Positive Regulation Of DNA Repair Meiotic Cell Cycle Cellular Response To Gamma Radiation Cellular Senescence
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Amyloid fiber formation
Drugs
Diseases
GWAS		Prostate-specific antigen levels ( 28139693)
Interacting Genes		42 interacting genes: CASC9 CBX8 CEP126 CSNK2B E2F6 FOXS1 H2AC18 H2AC20 H2AC4 H2AX H3-4 HSF2BP IMMT KAT5 KMT2A LRIF1 MAPK14 MLLT1 MUC1 NDEL1 PCBP2-OT1 PCGF3 PCGF6 PGR PHC1 PHC2 PTN RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D2 UBE2D3 UBE2I USP11 USP15 VPS11 WHRN ZBTB16	45 interacting genes: A2M ACTB ALG9 ATM ATR BARD1 BAZ1B BMI1 BRCA1 BRCA2 BRD1 CALM1 COPG1 DDX21 DHX9 EYA1 HUWE1 KAT5 MASP1 MDC1 MRE11 NBN NCL NGFR OTUB1 PAXIP1 PBK PPP1CA PRKDC PTEN PTPA QARS1 RNF8 RPS6KA3 SMARCA4 SUPT5H TAF1C TAF5L TERF2 TIAM2 TOPORS TP53BP1 TRAF6 TSSK6 WRN
Entrez ID		648	3014
HPRD ID		01277	03465
Ensembl ID		ENSG00000168283	ENSG00000188486
Uniprot IDs		P35226	P16104
PDB IDs		2H0D 2NA1 3RPG 4R8P 5FR6	1YDP 2AZM 2D31 2DYP 3SHV 3SQD 3SZM 3U3Z 6K1I 6K1J 6K1K
Enriched GO Terms of Interacting Partners?
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